How does bile duct cancer develop

How does bile duct cancer develop? As one of many cancer diseases, bile duct cancer has the characteristics of high incidence, difficulty in cure, and poor prognosis, which seriously threatens people's life and health. In order to prevent it as early as possible and stay away from bile duct cancer, we must actively understand the cause of the disease. So, how does bile duct cancer develop?

1. Liver fluke infection. A large number of experiments have shown that liver fluke infection is closely related to the occurrence of bile duct cancer. Liver flukes are usually hidden in fish and shrimp. Frequent consumption of raw fish is most likely to induce liver fluke infection. The worms themselves and their metabolites can cause long-term stimulation of the bile duct mucosal epithelium, which can easily lead to bile duct infection, bile stasis, fibrosis around the bile duct, and bile duct hyperplasia, and eventually lead to canceration and bile duct cancer.

2. Bile duct stones. In the clinical treatment of cholangiocarcinoma, it was found that about 1/3 of cholangiocarcinoma patients had cholangiolithiasis, and 5% to 10% of cholangiolithiasis patients would develop cholangiocarcinoma. This indicates that long-term stimulation of the bile duct by stones can easily lead to proliferative changes in the epithelium and induce the occurrence of cholangiocarcinoma.

3. Biliary duct cystic disease. Surveys show that the canceration rate of congenital common bile duct cysts can be as high as 17.5%, and the canceration rate of intrahepatic bile duct cysts is also 7%, which is more than 100 times higher than the incidence of bile duct cancer in the population. The canceration of bile duct cysts may be related to bile stasis in the cyst cavity, chronic infection, and the decomposition of bile acid into strong carcinogens. In addition, because bile duct cysts are often combined with abnormalities in the common channel of the bile membrane duct and reflux of membrane fluid, membrane enzymes act on the cyst mucosal epithelium for a long time, causing proliferative changes, which may promote the occurrence of cancer.

4. Primary sclerosing cholangitis. Sclerosing cholangitis is characterized by the proliferation of a large amount of fibrous tissue in the bile duct wall, which can cause localized or multiple segmental stenosis of the bile duct. Sometimes it is difficult to distinguish it from sclerosing cholangiocarcinoma. Most data show that the chance of primary sclerosing cholangitis developing cholangiocarcinoma is much higher than that of the general population, and the two are closely related.

A warm reminder to everyone: If you are unfortunately diagnosed with bile duct cancer, remember not to panic too much. Although bile duct cancer has a poor prognosis, if the patient chooses the correct treatment method, it can not only effectively improve the patient's quality of life, but also maximize the patient's life cycle. Be sure not to delay the treatment of the disease.