What is the current situation of small cell lung cancer

Small cell lung cancer is a type of bronchial lung cancer that mostly occurs in smokers. It seriously threatens people's health. Do you know about small cell lung cancer? Do you know what the current status of small cell lung cancer is? Let us learn about the current status of small cell lung cancer.

Small cell lung cancer (SCLC) accounts for about 15-20% of the total number of lung cancers. Compared with non-small cell lung cancer, its biological behavior is worse, the disease progresses rapidly, and it is easy to metastasize early. When diagnosed, about 60%-70% of patients are already in the late stage. It is currently believed that its occurrence is related to factors such as smoking, environment and genes. More and more evidence shows that autocrine growth loops, proto-oncogenes and tumor suppressor genes are related to the occurrence of small cell lung cancer. It is currently believed that SCLC originates from Kulchistky cells in the bronchial epithelium and mucous glands. Tumor cells have a more obvious neuroendocrine differentiation tendency and cause some abnormal endocrine syndromes in clinical practice, such as abnormal antidiuretic hormone syndrome, Cushing's syndrome, carcinoid syndrome, etc.

Small cell lung cancer (SCLC) is clinically and histologically unique in the field of lung cancer. Its widespread incidence and high mortality rate make it a health problem that has attracted worldwide attention. SCLC accounts for 13% of newly diagnosed lung cancer cases worldwide, with more than 180,000 cases each year. More than 90% of SCLC cases are current or former smokers, and the impact of smoking on the incidence of SCLC is positively correlated with the number of years and frequency of smoking. There are also rare cases with no smoking history [1]. Over the past 30 years, the annual incidence of SCLC has declined in highly industrialized countries, which may be related to changes in smoking patterns. At the same time, changes in the classification of lung cancer by the World Health Organization (WHO) may also partly contribute to this downward trend, as lung cancer subtypes that were previously considered to be unclear were later classified as non-small cell lung cancer (NSCLC). In regions and countries with a large number of smokers, such as Eastern Europe and Asia, the incidence of SCLC is still increasing, and due to its high mortality rate, it has caused huge losses to people's health and economic assets.