What is the best treatment for glioma

Glioma is a difficult problem in neurosurgery. Although comprehensive treatment with surgery as the main method has been adopted, its efficacy and prognosis are still not satisfactory. What is the best treatment method for glioma?

Surgical treatment of brain glioma:

At present, the treatment of glioma is still mainly surgery, supplemented by chemotherapy, radiotherapy, biological gene therapy and other comprehensive treatments. However, gliomas are prone to occur in important brain functions or nearby areas, have the characteristics of invasive growth, and have unclear boundaries with normal brain tissue. It is difficult to completely remove the tumor during surgery, and the postoperative mortality, disability and recurrence rates are all high. Therefore, the treatment of gliomas has always been a difficult problem and one of the important topics of medical research.

Gamma Knife Treatment for Glioma:

Gamma Knife has achieved satisfactory short-term results, whether as the first treatment or as a supplementary treatment for residual and recurrent tumors after surgery, especially for patients with low-grade tumors with small non-functional areas. Although there is still no fundamental change in long-term efficacy, Gamma Knife treatment is still very helpful in improving patients' symptoms, delaying recurrence, prolonging life, and improving quality of life.

Gamma Knife treatment of brain glioma development process:

Although Gamma Knife has made great progress in treating gliomas since the late 1980s, relevant standards have not been unified at home and abroad, and many treatment details are still not perfected. In the early stage of Gamma Knife treatment, although the growth of high-grade gliomas is inhibited and even the tumor shrinks, it will eventually recur due to its invasive growth characteristics. In order to better determine the tumor boundary, the tumor metabolism information image provided by PET can be used for positioning.

In addition, in order to reduce adverse reactions and improve efficacy, attention should be paid to the uniformity of tumor radiation dose. If there are too many targets during planning, the unevenness of tumor radiation dose will increase, forming a partial volume effect and increasing the incidence of cerebral edema; however, reducing the number of targets will affect treatment planning. Further research is needed on this.

Whether the combination of whole brain radiotherapy before or after Gamma Knife surgery is effective in controlling recurrence, prolonging survival and improving efficacy is still in the experimental stage and has not been confirmed by randomized large-sample prospective controlled studies. With the increasing application of Gamma Knife, more and more patients will choose Gamma Knife treatment in the future. I believe that in the near future, through the joint efforts of researchers, Gamma Knife treatment of glioma will achieve better results.