Understanding what glioma is

The incidence of tumors in modern society is getting higher and higher, so people's requirements for quality of life have also increased, and they are paying more attention to diseases. However, glioma, an unfamiliar disease, is threatening human health. How should we face this sudden disease? The following editor will lead you to understand glioma.

Like other tumors (diseases), gliomas are caused by the interaction of congenital genetic high-risk factors and environmental carcinogenic factors. Some known genetic diseases, such as neurofibromatosis (type I) and tuberculous sclerosis, are genetic susceptibility factors for brain gliomas. Patients with these diseases have a much higher chance of developing brain gliomas than the general population. In addition, some environmental carcinogenic factors may also be related to the occurrence of gliomas. Studies have shown that electromagnetic radiation, such as the use of mobile phones, may be related to the occurrence of gliomas. However, there is currently no evidence that there is an inevitable causal relationship between the two. Although most glioblastoma patients have had macrophage virus infection, and evidence of macrophage virus infection has been found in the vast majority of glioblastoma pathological specimens, it is not very clear whether there is a causal relationship between the two.

From the perspective of pathogenesis, glioma is caused by the interaction of internal genetic susceptibility factors and external environmental pathogenic factors, resulting in carcinogenic mutations (and combinations of mutations) at the level of cellular genetic material (DNA) and epigenetic material (epi-genetics); these mutations drive cells to continuously enter the cell cycle for mitosis, escape apoptosis, avoid cell growth contact inhibition, avoid immune inhibition, etc., and cause cells to obtain abnormal energy metabolism adapted to continued growth, induce tumor angiogenesis, hypoxia and necrosis and other changes.