Will bile duct cancer be passed on to the next generation after it is cured?

The age distribution of cholangiocarcinoma in my country is between 20 and 89 years old, and more men than women have cholangiocarcinoma. The treatment of cholangiocarcinoma is mainly surgery and radiotherapy, and chemotherapy is generally not sensitive. Cholangiocarcinoma is highly hidden and difficult to detect in the early stage, and it is very easy to relapse and metastasize in the middle and late stages. So will cholangiocarcinoma be inherited after it is cured?

Before introducing whether bile duct cancer is hereditary, we must first know the cause of bile duct cancer. How is bile duct cancer caused? It is transformed from normal cells. The division of cancer cells is like a "unbridled" wild horse that is difficult to control. When the number of cancer cells in human cells exceeds 1 million, some symptoms of bile duct cancer will occur. So how do normal cells mutate into cancer cells? For example, viruses, radiation, and chemicals act on the DNA in the cells, causing changes in its structure or function, which leads to changes in metabolism. Changes in cell proliferation become cancer cells. DNA is the basic substance of heredity. Once DNA changes, it will be passed on to the next generation. In this sense, bile duct cancer is related to heredity.

From a genetic point of view, both hereditary and non-hereditary cancers are caused by cell carcinogenesis. Modern research shows that one cell mutation is not enough to cause normal cells to become cancerous, and a second mutation is required for cancer to occur. The "second mutation" theory holds that if the first mutation occurs in a germ cell or a fertilized egg, then all the somatic cells of the individual produced by the division will bring about a mutation, which is a necessary condition for canceration, but not a sufficient condition for canceration; when any cell undergoes a second mutation in the future, the cell will be transformed into a cancer cell.

The above is an introduction to the issue of hereditary disease after bile duct cancer is cured. The main thing is that everyone can defeat the disease as soon as possible.