What factors are related to the occurrence of pituitary tumors

After the occurrence of pituitary tumors, there are many effects on the patient's body. One of the most obvious effects is infertility caused by pituitary tumors. It was discovered during hormone tests. The cause of pituitary tumors is also a topic that the medical community has been studying. So, what factors are related to the occurrence of pituitary tumors?

The cause of pituitary tumors is related to the dysfunction of hypothalamic regulation, because the patient's hypothalamic polypeptide hormone can promote the proliferation of pituitary cells. For example, after the patient is transplanted with GHRH gene, it can induce the proliferation of rat GH cells, and then as the disease progresses, it leads to the formation of pituitary tumors. In addition, the lack of inhibitory factors also has a certain promoting effect on the occurrence of tumors. For example, ACTH adenoma can occur in patients with primary adrenal cortex dysfunction. Therefore, patients need to pay more attention to their physical changes. Once abnormalities are found, they should be treated in time to avoid the occurrence of tumors.

Causes of pituitary tumors:

1. Genetics

Multiple endocrine neoplasia-1, Prop-1 excess, transcription factor defects

2. Hypothalamic lesions

Excessive GHRH or CRH, dopamine deficiency, receptor activation may

3. Pituitary signal transduction mutation

Abnormal growth factor and cytokine function

4. Oncogene activation or disruption of cell cycle regulation

5. Loss of tumor suppressor genes, mutation of oncogenes gsp, Ras, and PTTG-1

6. Environmental factors

Radiation effects, estrogen effects

7. Target gland (thyroid, gonads, adrenal glands) failure

Clinically, pituitary tumors are basically caused by one of these factors or a combination of several factors. Since we know that these factors can cause pituitary tumors, we must pay attention to them when they may occur. Actively preventing pituitary tumors can better ensure the health of the body.