What are the symptoms of mesenchymal chondrosarcoma

Clinically, osteosarcoma is a common tumor disease. Osteosarcoma is divided into many types according to its characteristics or causes. Mesenchymal chondrosarcoma is one of them. It mostly occurs in young and middle-aged people. The first mesenchymal chondrosarcoma originated from soft tissue. Today we will introduce in detail what are the symptoms of mesenchymal chondrosarcoma?

The main symptoms and signs of bone tumors include anemia, fatigue, malnutrition and cachexia. Local pain and tenderness are the most common, which may appear at the same time as or before the mass. The pain is mild at first, with intermittent dull pain, and then becomes continuous severe pain. Bone expansion and deformation and soft tissue masses can be felt in superficial areas. The skin is dark red, tense and shiny, and the skin temperature is increased. In a short period of time, a larger mass is formed, which can cause functional disorders, bone deformities and pathological fractures.

The main symptoms of mesenchymal chondrosarcoma are pain, swelling, lumps and joint stiffness that last for months to years. According to a report of 111 cases summarized by Nakashima et al., the bones invaded are the pelvis, femur, humerus, vertebrae, mandible and skull. Occasionally, there are reports of multicentric tumor growth in the periosteum and bones. The extraskeletal tissues are mainly affected by the meninges, lower limbs and orbits. The radiological changes of the tumor are mainly manifested as irregular soft tissue ossification, erosive bone destruction, bone sclerosis, periostitis, central calcification, etc. The radiological manifestations of the tumor are similar to those of general chondrosarcoma. The size of the tumor varies, the shape can be lobed, and the surface is wrapped with a fibrous membrane. Histologically, the tumor is characterized by a mixture of hyaline cartilage islands and malignant small cells, most of which originate from bone tissue and a few originate from soft tissue.

Radical surgical resection is the main method for treating mesenchymal chondrosarcoma. Radiotherapy and (or) chemotherapy are the main measures for non-surgical treatment, but there is no obvious and definite therapeutic effect. Local and adequate radical treatment is important for preventing recurrence and distant metastasis. Surgical resection plus adjuvant radiotherapy can be performed for resectable tumors of the pelvis, tibia, and proximal femur. Non-surgical treatment, especially for small cell tumors, can be performed with combined chemotherapy and radiotherapy similar to small cell sarcoma. Combination chemotherapy is better than single-dose chemotherapy for recurrent tumors.