Can I still have children if I have endometrial cancer?

Endometrial cancer is one of the three most common gynecological malignancies in women. Its incidence rate ranks first among gynecological malignancies in developed countries and second only to cervical cancer in my country. In recent years, the incidence of endometrial cancer has shown a trend of getting younger, with about 10% of patients under the age of 40. As women's childbearing age is gradually pushed back, the incidence of diseases that can affect fertility, such as polycystic ovary syndrome, obesity, and ovarian dysfunction, has increased year by year. Surveys show that up to 70% of endometrial cancer patients of childbearing age are still childless when diagnosed. The treatment of early endometrial cancer is, in principle, a staged surgery including total hysterectomy and bilateral oophorectomy, although the patient's 5-year survival rate after surgery exceeds 93%. But it is difficult for women who have not given birth to accept it. Some patients have a strong desire to retain their fertility. Is it feasible for patients with endometrial cancer to get pregnant?

After years of clinical exploration and practice, in 1961, the world reported the first successful application of high-efficiency progestins in the treatment of endometrial cancer to preserve fertility, which brought a ray of hope to endometrial cancer patients who have not conceived during their childbearing years. However, not all endometrial cancer patients who have not conceived during their childbearing years can preserve their fertility. Only those patients who meet the following conditions have the initial feasibility of preserving their fertility.

① Young people ≤ 40 years old who want to preserve their reproductive function;

② Pathologically confirmed stage IA, well-differentiated, type I endometrial adenocarcinoma with positive estrogen and progesterone receptors;

③Ultrasound and MRI examinations exclude myometrial infiltration, lymph node and distant metastasis, and ovarian tumors;

④ Normal serum marker CA125 level (<35IU/ml);

⑤Exclude systemic diseases such as abnormal cardiopulmonary function, acute liver and kidney function damage, and coagulation dysfunction

⑥ Exclude patients with a family history of hereditary non-polyposis colorectal cancer, a history of other tumors, or combined tumors in other parts of the body;

⑦ Follow-up can be guaranteed.

Patients who do not meet the above conditions should follow the doctor's advice and be treated according to the treatment principles of endometrial cancer.