Pathology and pathological classification of renal cancer

Kidney cancer is a relatively serious cancer. If you don’t pay attention or treat it poorly, it may turn into a malignant tumor. People are relatively unfamiliar with kidney cancer. Today, we will introduce some knowledge about kidney cancer based on its pathology and pathological classification.

pathology

Renal cancer originates from renal tubular epithelial cells, which are encapsulated and bright yellow on the cut surface. If the tumor is accompanied by bleeding, it will be red, brown or brown. It often has cystic changes and central necrosis. If there is calcification, it looks like leather. There are two types of cancer cells under the microscope. One is clear cell carcinoma, which is mainly composed of large polygonal cells. The cytoplasm contains more cholesterol. Since the cholesterol is dissolved during the sectioning process, the cells appear transparent under the microscope. This type of cancer cell is well differentiated. The other type is granular cell carcinoma, which has smaller cells and contains eosinophilic granules in the cytoplasm. This type of cell is poorly differentiated and has a higher degree of malignancy.

Kidney cancer is one of the major cancers that endanger human health. Its clinical symptoms can be varied. Its manifestations mainly appear gradually according to the progression of the patient's condition. It is easy to be ignored by the patient, which is very unfavorable for timely detection and treatment. Therefore, it is very necessary to know more about kidney cancer. So today, we will start with the pathological types of kidney cancer.

The common pathological types of renal cancer are as follows:

1. Renal clear cell carcinoma

Renal clear cell carcinoma has a high incidence and is the most common, generally accounting for 60% to 85%. Renal clear cell carcinoma is a malignant tumor composed of tumor cells with clear or eosinophilic cytoplasm, and there is a fine network of blood vessels in the tumor. It often occurs in both kidneys, and cysts, necrosis, hemorrhage and calcification are common in the tumor. Imaging can show calcification shadows.

2. Bellini collecting duct carcinoma

Bellini collecting duct carcinoma is common in middle-aged and elderly people, with an incidence of about 1 to 2 percent. Bellini collecting duct carcinoma is a malignant epithelial tumor originating from the Bellini collecting duct. Patients often experience abdominal pain, rib masses, and hematuria. It often metastasizes to the bones. The tumor is mostly solid and grayish white, with visible necrosis and satellite nodules.

3. Papillary renal cell carcinoma

Although the incidence of papillary renal cell carcinoma is about 7% to 14%, it is also common in renal cancer patients. Papillary renal cell carcinoma is a malignant tumor of the renal parenchyma with papillary or tubulopapillary structures, often accompanied by hemorrhage, necrosis and cystic changes. The tumor tissue is fragile and may have a pseudocapsule. It often occurs in both kidneys.

4. Renal chromophobe cell carcinoma

As a type of renal cancer pathology, renal chromophobe cell carcinoma has less obvious symptoms and is easily ignored by patients. Its incidence rate is about 4 to 10 percent. The cancer cells of renal chromophobe cell carcinoma are large and lightly stained, with clear cell membranes, no special symptoms and signs, and imaging examinations often show a mass without necrosis and calcification.

Warm reminder: the symptoms of kidney cancer are not obvious. If careful patients find that there is something wrong with their body, it is best to go to the hospital for examination and diagnosis in time, and then receive timely treatment to avoid worsening of the disease and increase the difficulty of treatment.