What causes kidney cancer in children

Kidney cancer is a serious cancer cell transformation disease. In recent years, due to the improvement of living standards, the number of kidney cancer patients has also increased significantly, and the degree of harm to people has become more and more serious. So now let's first understand what are the causes of kidney cancer in children? What are the related factors?

Medical research has found that children do not easily develop cancer, but if there are patients, more than 90% of them are Wilms tumors, and about 1 in every 10,000 children in the world suffers from Wilms tumors. Researchers at Massachusetts General Hospital said that about 30% of children's Wilms tumors are related to a gene mutation called WTX.

Experts say that the onset of nephrotic cell tumors in children is usually around 5 years old. Generally, the survival rate after nephrectomy and chemotherapy is about 80%. In addition, about 20% of patients will have tumor recurrence, leading to death. If the mutation of this related gene can be identified in advance, it can help doctors better predict the risk of tumor recurrence and develop more targeted treatment plans.

In addition, the cause of the disease in children is that the WTX gene is located on the X chromosome that determines the sex of the human body. Its special location deserves attention. Most tumor suppressor genes lose their activity usually because one allele is missing and the other allele mutates and cannot be expressed. However, the genes on the human X chromosome have only one functional allele, so the researchers speculate that the WTX tumor suppressor gene may only need one stimulus to cause inactivation. This discovery shows that the impact of genes on the X chromosome on cancer exceeds the original estimate.

The above experts have explained to everyone the causes of severe kidney cancer in children. Most of them are due to genetic effects. In life, it is not only necessary to understand this knowledge, but also the common sense about kidney cancer that patients should know.