Hereditary papillary renal carcinoma

Many kidney cancer patients are very worried about whether their disease will be inherited. In fact, this is not surprising. We can see such a situation around us. Among several generations of relatives of a person, many people have lost their lives to kidney cancer. Therefore, people think that kidney cancer is hereditary. Clinically, kidney cancer can be divided into many types. Some kidney cancer diseases are not inherited, but some are definitely inherited. So what are the symptoms of hereditary papillary renal cancer?

1. VHL disease is an autosomal dominant genetic disease and a familial tumor syndrome involving multiple systemic lesions. Its clinical features include: hemangioblastomas of the cerebellum, retina, and spinal cord, renal cell carcinoma, pheochromocytoma, and renal cysts. All pathological types are clear cell carcinomas. Clinically, VHL renal cancer is mostly bilateral multiple renal cancer, which progresses slowly and metastasizes late. It is generally believed that when the tumor is small, it can be observed clinically. When the tumor diameter is greater than 3 cm, tumor resection can be performed and the residual kidney can be preserved as much as possible.
2. Hereditary papillary renal carcinoma is an autosomal dominant genetic disease, and the pathological type of the tumor is all type I papillary renal carcinoma. The clinical characteristics of HPRC are similar to those of VHL disease renal carcinoma, mostly bilateral multiple renal cancers, with a later age of onset and slower progression. It is generally recommended to perform tumor resection when the tumor is large.
3. Hereditary leiomyoma renal cancer is an autosomal dominant genetic disease, manifested as renal cancer with multiple skin leiomyoma, multifocal uterine leiomyoma or uterine leiomyosarcoma, among which the pathological type of renal cancer is mostly type II papillary renal carcinoma. The clinical characteristics of HLRCC are significantly different from other types of hereditary renal cancer. HLRCC is mostly a single tumor occurring on one side, with an early onset age, strong invasiveness, and easy early metastasis. Therefore, early diagnosis and surgical treatment are very important.