Can liver cancer and laryngeal cancer be inherited?

We have indeed found that liver cancer has a family clustering phenomenon. In some patients, 4 or 5 people in a family have liver cancer. Such case reports can also be seen frequently in medical journals. So is liver cancer hereditary? In this regard, we have specially consulted the latest literature reports at home and abroad, and here we will give you an explanation.

Liver cancer is a polygenic hereditary disease

As to whether liver cancer is a genetic disease, experts at home and abroad have basically reached a consensus: liver cancer is a multi-gene genetic disease, and its occurrence is the result of the combined effects of genetic and environmental factors. In other words, genetic factors are the basis, which determines the susceptibility of the human body to tumors; environmental factors are the inducement, which contributes to the occurrence of liver cancer.

Studies have found that genetic polymorphisms of some genes related to immunity, inflammation, DNA repair, cell proliferation, apoptosis, carcinogenic compounds, and alcohol metabolism and detoxification are closely related to susceptibility to liver cancer. For example, the liver is an important detoxification organ in the human body. Some people have a strong ability to degrade carcinogens, so less is accumulated in the body, while others have a poor detoxification ability and more is accumulated, which is the polymorphism of the human body's toxic metabolism enzymes. It determines the different susceptibility of individuals to chemical carcinogens and mutagens in the environment, thus leading to different susceptibility to tumors.