The incidence of gallbladder cancer is related to the following factors

Generally, women over 60 are more likely to develop gallbladder cancer. Gallbladder cancer often occurs in the gallbladder body, and invasive adenocarcinoma is the most common. So what are the causes of gallbladder cancer ? The following is a detailed answer from relevant experts.

1. Ulcerative colitis

The incidence of biliary tumors in this type of patients is 10 times that of the general population, but the exact cause is unknown and may be related to changes in bile acid metabolism.

2. Abnormal common channel of bile duct

This situation can easily lead to the flow of membrane fluid into the biliary system. The activated membrane enzymes can damage the gallbladder epithelium and cause chronic inflammation, gradually leading to atypical hyperplasia and cancer.

3. Gallbladder adenoma and adenomyomatous hyperplasia

Gallbladder adenoma is a benign tumor originating from the mucosal epithelium, but in recent years it has been found to have a high rate of canceration. Tumors larger than 10 mm, without sessile or with a wide base have a greater chance of canceration. The disease has now been basically identified as a precancerous lesion and is receiving increasing attention.

4. Gallstones

Many studies have suggested that gallstones are one of the important causes of gallbladder cancer, because the proportion of gallbladder cancer with gallstones is as high as 60%-100%, and the rate of gallbladder stone patients suffering from gallbladder cancer in the future can reach 3%-14%, which is several times higher than those without stones. Moreover, the larger the stone, the higher the risk of gallbladder cancer. It is generally believed that this is related to the long-term stimulation of gallstones on the gallbladder mucosa or the concurrent chronic inflammation leading to gallbladder mucosal hyperplasia, and then atypical hyperplasia and canceration.

The above is an introduction to the causes of gallbladder cancer. I believe everyone should have a certain understanding of gallbladder cancer. If you want to know more about gallbladder cancer, please consult online experts.