Experts summarize the causes of bladder cancer

Bladder cancer is a common tumor in the urinary system. It is most common in the side and back walls of the bladder, followed by the triangular area and the top. Bladder cancer is very harmful to the human body. So what are the causes of bladder cancer ? The following is a detailed answer from relevant experts.

① Workers who are exposed to aromatics for a long time, such as dyes, leather, rubber, and painters, may have a higher incidence of bladder tumors. It has been calculated that the incidence rate among workers exposed to aniline is 30 times higher than that of the general population. Benzidine, 4,4-diaminobisphenyl, 4-aminobisphenyl, etc. are all considered to be relatively certain foreign chemical carcinogens. This is one of the causes of bladder cancer. After these substances enter the body, they are metabolized by the liver and excreted into the bladder with urine, and then decomposed into α-aminonaphthoic acid by glucuronidase, making it carcinogenic and causing occupational bladder cancer. However, the incubation time of cancer is relatively long, up to about 20 years.

② Smoking is also a cause that increases the incidence of bladder tumors. Recent studies have shown that the metabolism of the carcinogenic substance tryptophan in smokers' urine increases by 50%. When smoking stops, tryptophan levels gradually return to normal. It has also been found that vitamin C can reduce the activity of tryptophan in both smokers and non-smokers.

③ Abnormal tryptophan metabolism in the body. Abnormal tryptophan metabolism can produce some metabolites, such as 3-hydroxy-2-aminoacetophenone and 3-hydroxy-o-aminobenzoic acid, which can directly affect the synthesis of RNA and DNA in cells. These metabolites are excreted into the bladder through the liver and have carcinogenic effects after being acted on by glucuronidase. The concentration of these carcinogens in the urine of patients with bladder tumors is often significantly increased. This is also a cause of bladder cancer.

The above is an introduction to the causes of bladder cancer. I believe everyone should have a certain understanding of bladder cancer. If you want to know more about bladder cancer, please consult online experts.