Kidney cancer symptoms may appear in different ways

The most common disease in the oncology department includes kidney cancer. Generally, the symptoms of kidney cancer are not single, and there may be other manifestations. So do you know what the main symptoms of kidney cancer are? This question is often asked by people, so let the experts explain it in detail below.

Kidney cancer symptoms can be divided into three categories:

1. Common (clear cell) renal cell carcinoma is the most common type, accounting for 70% to 80% of renal cell carcinoma. Under the microscope, the tumor cells are large, round or polygonal, with abundant cytoplasm, transparent or granular, and the stroma is rich in capillaries and sinusoids (Figure 11-23). ​​Most cases of this type are sporadic, and a few are familial and accompanied by VHL syndrome. The symptoms of this type of renal cancer are related to changes in the VHL gene.

2. Papillary carcinoma accounts for 10% to 15% of renal cell carcinoma. Symptom types of renal cancer include basophils and eosinophils. Tumor cells are cuboidal or short columnar and arranged in a papillary shape. Sand bodies and foam cells are common in the axial stroma of the papilla, and edema may occur. This type also includes familial and sporadic types. The occurrence of papillary renal cancer symptoms has no obvious relationship with VHL. The cytogenetic changes of sporadic papillary renal carcinoma are mainly trisomy of chromosomes 7, 16 and 17 and loss of chromosome Y in male patients [t(X,1)], while the changes of familial papillary renal carcinoma are mainly trisomy of chromosome 7. The occurrence of familial clear cell carcinoma is related to the mutation of the proto-oncogene MET located on chromosome 7.

3. Chromophobe cell carcinoma accounts for about 5% of renal cell carcinoma. Under the microscope, the cells are of different sizes, with light-stained or slightly eosinophilic cytoplasm, relatively concentrated cytoplasm near the cell membrane, and often with halos around the nucleus. This type of tumor may originate from the collecting tubule epithelial cells and has a good prognosis. Cytogenetic examinations often show multiple chromosome deletions and severe hypodiploidy. The missing chromosomes include chromosomes 1, 2, 6, 10, 13, 17 or 21, which can also cause symptoms of renal cancer.

The above is an introduction to the symptoms of kidney cancer. Do you understand it? I hope that if patients find that they have the disease, timely treatment is the most important thing. Of course, they must face this disease squarely and receive treatment seriously to ensure their health.

For more information, please visit the kidney cancer special topic at http://www..com.cn/zhongliu/sa/ or consult an expert for free. The expert will then give a detailed answer based on the patient's specific situation.