Common knowledge about chemotherapy of nasopharyngeal tumors

Chemotherapy is an auxiliary treatment method for nasopharyngeal tumors, which has a more direct inhibitory and killing effect on cancer cells. Below, the knowledge of chemotherapy for nasopharyngeal tumors is introduced from the following aspects.

1. Indications for chemotherapy of nasopharyngeal tumors

(1) Patients in stage IV and those with obvious lymph node metastasis;

(2) Any patient suspected of having distant metastasis;

(3) For patients with large lymph node metastases in the cervical region, induction chemotherapy should be performed before radiotherapy;

(4) Chemotherapy as a sensitizer before radiotherapy;

(5) As adjuvant chemotherapy after radiotherapy or surgical treatment.

2. Commonly used combined chemotherapy regimens

(1) PF regimen: 20 mg/m2 of cisplatin and 750 mg/m2 of 5-fluorouracil, intravenous drip, for 5 consecutive days followed by a 2-week break, for 2 to 3 courses. This regimen can be used to shrink tumors before radiotherapy or for cases of chemotherapy alone, with an effective rate of 40% to 90%. It is the most commonly used chemotherapy regimen for nasopharyngeal tumors.

(2) PFA regimen: 20 mg of cisplatin and 500 mg of 5-fluorouracil, intravenous drip for 5 days; 40 mg of doxorubicin, intravenous injection on the first day of treatment. Repeat once after 3 to 4 weeks, it has a significant effect on shrinking tumors. It is now rarely used.

(3) CBF regimen: 600-1000 mg of cyclophosphamide per time, intravenous injection, applied on the 1st and 4th days. 15 mg of bleomycin per time, intramuscular injection, applied on the 1st and 5th days. 5-fluorouracil 500 mg, intravenous injection, applied on the 2nd and 5th days. Rest for 1 week after the end of the treatment course, a total of 4 courses of treatment. The effective rate is 60.8%. It is rarely used now.

The above is the knowledge about chemotherapy for nasopharyngeal tumors. I hope patients can learn more about this aspect and have a clear idea during treatment.

Nasopharyngeal tumor: http://www..com.cn/zhongliu/bya/byzl.html