What is the cause of colon cancer?

The exact cause and mechanism of colon cancer, like other tumors, is still not completely clear. From an epidemiological point of view, the incidence of colon cancer is related to the environment, living habits, and especially the diet.

Studies have shown that a diet high in saturated fatty acids can increase the concentration of bile acid and neutral sterols in the colon and change the composition of the intestinal flora. Bile acid can generate carcinogens such as 3-methylcholanthrene through bacterial action, and sterol rings can also be aromatized by bacteria to form carcinogens. Dietary fiber includes cellulose, pectin, hemicellulose, lignin, etc., which absorbs water, increases the amount of stool, dilutes the concentration of intestinal residues, shortens the time for stool to pass through the large intestine, and reduces the time that carcinogens come into contact with the intestinal mucosa. If dietary fiber is insufficient, it is already one of the causes of colon cancer.

The incidence of colorectal cancer in patients with chronic colorectal inflammation, such as ulcerative colitis, is higher than that in the general population. During the development of inflammatory proliferative lesions, polyps may often form and further develop into colorectal cancer. In Crohn's disease, cancer may occur in patients with colon and rectum involvement.

There is a significant difference in the incidence and mortality of colon cancer between schistosomiasis-endemic areas and non-endemic areas. In the past, it was believed that patients with chronic schistosomiasis would suffer from chronic ulcers of the large intestinal mucosa, inflammatory polyps, etc. due to the deposition of schistosome eggs and toxin stimulation in the intestinal wall, which in turn caused cancer.

According to general statistics, the incidence of colon cancer in patients with colon polyps is five times that of patients without colon polyps. The incidence of cancer is even higher in familial multiple intestinal polyposis.

In recent years, there have been reports of families with positive colon cancer whose incidence rate is four times that of the general population, indicating that genetic factors may be involved in the development of colon cancer.

The above is some knowledge about colon cancer. Expert Tips: If you have symptoms of disease, you can choose the appropriate treatment according to your symptoms, but do not delay diagnosis, and do not let your life be ruined by hesitation. You should go to a regular hospital for treatment in time to avoid delaying the disease and causing serious consequences. If you have other questions, please consult our online experts or call for consultation. Believe in miracles, and wish you health, happiness, and joy!

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