Detailed causes of malignant lymphoma

Malignant lymphoma is an immune cell tumor of lymph nodes and extranodal lymphoid tissue, which originates from the malignant transformation of lymphocytes or tissue cells. So what are the causes of malignant lymphoma? Let's take a look at the analysis of our experts:

The causes of about half of malignant lymphomas are not yet fully understood. Most clinical data analysis shows that the causes of lymphoma are related to viruses, immune deficiency, bacterial infection, ionizing radiation, genetic factors, etc. The specific analysis of the causes of malignant lymphoma includes the following points:

1. Immune factors: Malignant lymphoma is a malignant tumor of the immune system, and immune deficiency is an important cause of malignant lymphoma. Under normal circumstances, the human immune system has an immune surveillance function, which can reject and eliminate mutated or cancerous cells in the body. Patients with immune deficiency are prone to infection, especially viral infection.

2. Virus etiology: Viruses are an important topic in the study of tumor etiology. According to the current research on relevant data, Epstein-Barr virus, human T-lymphotropic virus, and human B-lymphotropic virus are closely related to malignant lymphoma.

3. Physical causes: The cause of malignant lymphoma is not only related to the absorbed radiation dose, but also to the age at the time of exposure. The incidence of malignant lymphoma in people under 30 years old who have been exposed to radiation is higher than that in other people who have not been exposed to radiation. The impact of medical radiation on the incidence of human tumors has received increasing attention, especially high-dose radiation has a promoting effect on the incidence of human malignant lymphoma.

4. Chemical etiology: Alkylating agents, aromatic amine compounds, and polycyclic aromatic hydrocarbon compounds in chemical carcinogens are related to the causes of malignant lymphoma. The incidence of malignant lymphoma caused by chemical drugs is not uncommon. For example, there are reports of malignant lymphoma caused by drugs such as cyclophosphamide, L-phenylalanine nitrogen mustard, and methyl procarbazine. The use of pesticides and chemical fertilizers in agriculture has also led to a continuous increase in the incidence and mortality of malignant lymphoma.

5. Genetic factors: There are many reports on the relationship between genetic factors and the etiology of malignant lymphoma. Sometimes, obvious family clustering can be seen, such as brothers and sisters may suffer from malignant lymphoma successively or simultaneously.

6. Other factors: Lymphoma is often accompanied by chromosomal abnormalities. For example, Hodgkin's disease often has tri- or tetraploidy, and Burkitt's lymphoma and follicular lymphoma often have chromosomal changes such as t(14:18). The relationship between drugs and lymphoma occurrence has been preliminarily confirmed.

The above is an introduction to the various causes of malignant lymphoma. Generally speaking, the most common causes of malignant lymphoma are immune dysfunction and viral infection. Appropriate preventive measures can be taken for specific causes. For example, pay attention to diet, supplement nutrition, and exercise regularly to improve your immune function and reduce the incidence of malignant lymphoma. If you have other questions, please consult our online experts, who will answer your questions in detail.

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