Lynch syndrome and endometrial cancer

Lynch syndrome patients have a significantly increased risk of endometrial cancer and are advised to undergo regular gynecological examinations and cancer screening.

Lynch syndrome is a hereditary disease associated with mutations in DNA repair genes, which often leads to a high incidence of certain cancers, including endometrial cancer, colorectal cancer, etc. For women, endometrial cancer may be one of the early manifestations of cancer, especially women of childbearing age or even postmenopausal women should be extra vigilant.

Early symptoms of endometrial cancer generally include abnormal vaginal bleeding, increased secretions and other discomfort. Some patients may mistakenly think that it is a normal condition after menopause or irregular menstruation, thus delaying medical treatment. It may also be accompanied by abdominal pain, weight loss and other symptoms. Compared with ordinary people, patients with Lynch syndrome may experience these symptoms at a younger age, so they should remain highly vigilant.

For this high-risk group, it is recommended to give priority to preventive hysterectomy, which is one of the important means to reduce the risk of cancer. For those who are not considering preventive surgery for the time being, transvaginal ultrasound examination or endometrial biopsy is required every year to detect signs of cancer as early as possible. If abnormal signs are found, you should seek medical attention immediately, and further clarify the diagnosis and timely treatment through pathological examination and imaging examination.