What are the chemotherapy options for colorectal cancer?

The treatment of colorectal cancer is surgical resection of the tumor as the first choice, supplemented by radiotherapy, chemotherapy drugs and traditional Chinese medicine. Recently, many scholars have used endoscopic resection for early colorectal cancer and achieved good results. Preoperative systemic chemotherapy for colorectal cancer patients is mostly continuous intravenous infusion through peripheral veins or oral administration.

Neoadjuvant chemotherapy is one of the methods for preventing postoperative liver metastasis that has attracted much attention in recent years. Regional arterial infusion chemotherapy for solid malignant tumors is one of the neoadjuvant chemotherapy methods. The killing effect of chemotherapy drugs on tumor cells depends on their concentration in the local tumor. For every 1-fold increase in drug concentration, its killing effect on tumor cells increases 10 times. Regional arterial infusion chemotherapy is a treatment plan designed to increase the local drug concentration in the tumor.

Patients with distant metastasis of colorectal cancer can only achieve long-term survival if they receive radical resection, and patients who receive systemic preoperative chemotherapy often have a high resection rate. However, the disadvantage of preoperative chemotherapy is the low responsiveness of tumors to traditional chemotherapy drugs and chemotherapy routes. For patients with previously unresectable liver metastases (tumor diameter greater than 5cm, more than 4 nodules or poorly located masses), three-drug combination chemotherapy is implemented, and then the patient's condition is evaluated. For patients who have the opportunity for resection, metastases are resected.

In addition, for some patients with low-position locally advanced disease who are temporarily unable to undergo anal preservation surgery due to the low tumor location and large invasion range, new preoperative treatment methods need to be sought. Appropriate doses of combined preoperative radiotherapy and chemotherapy can reduce the tumor stage, improve the resection rate, and obtain more opportunities for anal preservation with less toxic reactions. For patients with low-position disease in the still-stage, most patients can preserve the anal sphincter through preoperative radiotherapy and chemotherapy, and the sphincter functions well, which improves the quality of life of patients.

The above is a brief introduction to "What are the chemotherapy options for colorectal cancer?" For people who are related to the pathogenic factors of colorectal cancer, it is recommended to take preventive measures for colorectal cancer and carry out specific treatment according to the doctor's instructions. I hope that patients can recover soon! If you have other questions about colorectal cancer, please consult our experts online or call for consultation.

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