What are the symptoms of advanced prostate cancer?

Prostate cancer is the most important type of tumor in the male urogenital system. It is a disease unique to humans and is extremely rare in other mammals. Prostate cancer is the second leading cause of cancer death in men, second only to lung cancer. Prostate cancer can generally be divided into four stages clinically. When prostate cancer develops to the late stage, bone metastasis of cancer cells will occur. The following is a detailed introduction to the relevant symptoms of late-stage prostate cancer.

Bone metastasis is the main manifestation of late-stage prostate cancer. Prostate cancer is the malignant tumor most likely to metastasize to the bone, and more than 80% of prostate cancer patients will develop bone metastasis.

Bone metastasis lesions can be found in the ilium, vertebrae, ribs, skull and proximal ends of long bones, etc., mostly occurring in the blood-rich parts of the bone axis. The most common and earliest clinical manifestation of prostate cancer bone metastasis is bone pain. Continuous dull pain often affects the patient's appetite and daily rhythm of life, causing the patient to become increasingly emaciated and in great pain. Secondly, because the bones are "eaten" by tumor cells bit by bit, the metastatic bones are prone to pathological fractures. If tumor cells invade the patient's spinal vertebrae, then the collapse of the vertebrae will cause symptoms of spinal cord compression, which will make treatment more difficult.

Most patients with prostate cancer bone metastasis are found because they go to the hospital orthopedic department for treatment due to pain in a certain part of the body. Unfortunately, however, by this time, prostate cancer has already developed to the late stage. Therefore, it is very important to detect prostate cancer early.

At present, the generally accepted and effective method for early detection of prostate cancer in clinical practice is rectal digital examination plus serum PSA concentration measurement. Rectal digital examination can detect the hardened area of ​​prostate cancer. Careful and careful rectal digital examination is of great significance for the early diagnosis and staging of prostate cancer. If suspicious hardened stool is found, further prostate puncture biopsy is required, and about 70% of patients can be diagnosed. PSA is a specific serum indicator for prostate cancer, and normal people are generally ≤4ng/ml. If it is higher than this indicator, it will attract the attention of the doctor. For men over 45 years old, it is best to visit the urology clinic every 3 months to 6 months for a detailed prostate-related examination.

Early prostate cancer is often sensitive to male androgen resistance therapy. However, as the disease progresses, this androgen resistance therapy will gradually lose its effect, and prostate cancer will also develop to the late stage.

In addition to endocrine therapy (androgen resistance therapy) and bisphosphonate therapy, the treatment of prostate cancer bone metastasis can also use chemotherapy, external radiation therapy, radionuclide internal radiation therapy, and the combination of various therapies according to different conditions. In addition, more cutting-edge treatments, such as immunotherapy and gene therapy, are still in the experimental research stage and have few clinical applications, but they have very broad application prospects.

The above is some knowledge about advanced prostate cancer that we have prepared for you today. We hope it will be helpful to you. If you have any other needs, you can also consult our online consulting experts. We are always here to answer your questions.

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