What are the causes of kidney cancer in children?

In recent years, kidney cancer has become one of the major diseases that endangers society and human health, and it has brought great pain and distress to humans. In order to reduce the incidence of kidney cancer, we humans should master the genes related to childhood kidney cancer:

More than 90% of childhood kidney cancers are Wilms tumors, and about 1 in 10,000 children worldwide suffer from Wilms tumors. Researchers at Massachusetts General Hospital said that about 30% of childhood Wilms tumors are related to mutations in a gene called WTX.

Researchers said that the age of onset of nephroblastoma is usually around 5 years old, and the survival rate after surgery is about 80% through nephrectomy and chemotherapy. In addition, about 20% of patients will experience tumor recurrence, leading to death. If the mutation of this associated gene can be identified in advance, it can help doctors better predict the risk of tumor recurrence and develop more targeted treatment plans.

The researchers pointed out that the WTX gene is located on the X chromosome, which determines sex in the human body. Its special location deserves attention. Most tumor suppressor genes lose their activity usually because one allele is missing and the other allele mutates and cannot be expressed. However, the genes on the human X chromosome have only one functional allele, so the researchers speculate that the WTX tumor suppressor gene may only need one stimulus to cause inactivation. This discovery shows that the impact of genes on the X chromosome on cancer exceeds the original estimate.

The above are the genes related to childhood kidney cancer. Expert Tip: If you have symptoms of illness, do not delay diagnosis and go to a regular hospital for treatment in time to avoid delaying the disease and causing serious consequences. If you have other questions, please consult our online experts or call for consultation.

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