Many people suffer from anemia, but no one pays attention to how much harm anemia can cause to their body. In fact, frequent anemia can also affect their eyes and eventually cause swelling of the eyes. At this time, you need to treat the anemia problem first. Only in this way can your condition improve faster and without too many sequelae. 1. Medical history 1. The onset, development and characteristic manifestations of anemia. 2. Whether there are any pathogenic factors. 3. Whether there are chronic diseases that cause anemia. 4. Whether there are genetic factors. 5. Response to commonly used anti-anemia drug treatment. (II) Physical examination, symptoms and signs, and associated symptoms 1. Skin and mucous membranes: Anemia can cause pale skin, nail beds, lips, and conjunctiva, and decreased skin elasticity. 2. Jaundice: Large amounts of hemolysis can cause yellowing of the skin and sclera. 3. Oral cavity: The tongue becomes pale, the tongue surface becomes smooth and painful due to iron and vitamin deficiency, oral mucosal ulcers occur, and patients with aplastic anemia may develop acute pharyngitis. 4. Circulatory system: rapid breathing, increased heart rate after activity, breath holding, long-term anemia can cause anemic heart disease, tachycardia, heart murmur, etc. 5. Digestive system: Iron deficiency can cause pica, a tendency to like eating dirty food. Ischemia of the digestive tract mucosa, weakened digestive ability, and decreased appetite. 6. Urinary system: After hemolysis, soy sauce-colored or strong tea-colored hemoglobinuria appears. 7. Reproductive system: Iron deficiency can cause excessive menstruation and menstrual disorders in women, and decreased libido in men. 8. Others: Acute hemolysis may cause pain in the waist and back, and severe anemia often causes dizziness, tinnitus, and fainting. 3. Laboratory examination 1. General hematological examination: routine blood test, reticulocyte count, red blood cell index determination, blood picture observation of red blood cell morphology, and bone marrow examination. 2. Special hematological examinations: iron metabolism examination, serum folate and vitamin B12 concentration determination, screening test, etc. Bone marrow necrosis, myelofibrosis, myelosclerosis, marble disease, bone marrow metastasis of various extramedullary tumor diseases, and various infectious or non-infectious osteomyelitis can all affect blood cell production and lead to anemia due to damage to bone marrow stromal cells and the hematopoietic microenvironment (which can also damage hematopoietic cells). (2) Anemia caused by hyperfunction of lymphocytes T cell hyperfunction can lead to hematopoietic failure through direct killing of cytotoxic T cells (perforin) or (and) T cell factor-mediated hematopoietic cell apoptosis. Hyperfunction of B cells can produce anti-bone marrow cell autoantibodies, which in turn destroy or inhibit hematopoietic cells and lead to hematopoietic failure (immune-related pancytopenia). |
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