What are the early symptoms of bone hematopoiesis?

There is a certain standard for healthy bones. Bone quality cannot be too low or too high, otherwise it will cause great damage to people's health. Because problems with bones will cause various functional defects. For example, bone hematopoietic dysfunction is a more serious problem that can threaten life safety. Let's take a look at the early symptoms of bone hematopoietic dysfunction.

Myelofibrosis

This disease is characterized by varying degrees of bone marrow fibrosis and extramedullary hematopoiesis, which mainly occurs in the spleen and secondarily in the liver and lymph nodes. The typical clinical manifestations are erythroblastic and myeloid anemia with a large number of teardrop-shaped red blood cells. Bone marrow puncture often shows dry tapping, the spleen is often significantly enlarged, and there are varying degrees of bone sclerosis. This disease is a rare disease with an incidence rate of 0.2/100000 to 2/100000. The age of onset is mostly between 50 and 70 years old, and can also be seen in infants and young children, with males slightly more likely to be infected than females.

Most cases of this disease have a slow onset, and there may be no symptoms in the early stages. Later, fatigue, night sweats, palpitations, paleness, shortness of breath and other weak symptoms, as well as abdominal pain, abdominal mass, bone pain, jaundice, etc. will gradually appear. Most cases of this disease progress slowly, with a course of 1 to 30 years, and some may turn into acute leukemia. A minority of patients present with acute myelofibrosis, which has a short and severe course and usually leads to death within 1 year. The main manifestations of this disease are:

1. Gradual fatigue, weight loss and weakness.

2. Skin and mucous membranes are pale and purpuric.

3. Some patients experience bone and joint pain, renal colic, fever, discomfort, heaviness, pressure or pain in the left upper abdomen.

4. Hepatosplenomegaly, with splenomegaly being the most prominent.

5. Patients in the late stage may have severe anemia and bleeding.

treat

1. Anemia can be treated with oral stanozolol or intramuscular injection of testosterone propionate.

2. Prednisone can be added if hemolysis occurs.

3. Patients with high white blood cell counts and significant splenomegaly may benefit from low-dose chemotherapy.

4. Interferon and 1,25-hydroxyvitamin D3 can be tried.

5. Splenectomy may be considered for patients with severe compressive symptoms or splenic infarction caused by enlarged spleen, obvious splenic thrombocytopenia, refractory hemolysis and portal hypertension.