The role of dimethyl sulfoxide

Dimethyl sulfoxide is a substance that can be used in many industries and can help people solve many problems. In pharmaceutical production and medical treatment, dimethyl sulfoxide is widely used. It can be used to treat a variety of diseases and restore patients to health. Below, we will introduce in detail the specific applications of dimethyl sulfoxide in pharmaceutical production, medical treatment and pesticides.

1. Application in pharmaceutical production

DMSO is widely used as a reaction solvent in the synthesis of pharmaceutical intermediates. For example, potassium fluoride is reacted with 3,4-dichloronitrobenzene in DMSO to produce fluorochloroaniline, which is widely used in the production of norfloxacin and other fluorine-containing drugs. India is one of the major countries producing fluorinated drugs, so the annual import volume of DMSO is about 4,500 tons. DMSO has been used in the synthesis of berberine, inositol nicotinate, sucrose fatty acid polyesters and in the extraction of traditional Chinese medicine.

2. Application in Medical Treatment

DMSO has solubility and permeability to many drugs, and has anti-inflammatory and analgesic effects, promotes blood circulation and wound healing, and has diuretic and sedative effects. It can increase drug absorption and improve efficacy, so it is called "panacea" abroad. Various drugs dissolved in DMSO can penetrate into the body by applying them on the skin without oral administration or injection, opening up a new way of drug delivery. More importantly, it increases the local drug content in the affected area and reduces other drug hazards in the body. There are many reports on medical research abroad. In the 1960s, China's Shenyang Pharmaceutical College, Beijing Institute of Materia Medica, China Drug Testing Center, etc. conducted comprehensive toxicological tests and pathological anatomy to prove that the half-quantity LG50 value of DMSO in China is (22.4±1.4) g/kg, which is basically consistent with the 21.4g/kg reported in foreign literature, and is non-toxic, which is consistent with the findings of pathological anatomy.

The Beijing Institute of Materia Medica used sarcoma-lytics, B518, C6323, N-A and other drugs to apply sarcoma-lytics locally to the tumor, achieving good therapeutic effects and significantly inhibiting tumor growth. In animal experiments, after anatomical testing, the local drug concentration was found to be 2 to 8 times higher than that of other drugs. Foreign studies believe that cancer cells have a layer of keratin protective membrane that hinders the entry of drugs. DMSO has the ability to dissolve and penetrate keratin, so it can improve the efficacy. In the 1960s, 160 medical institutions including Peking Union Medical College Hospital conducted clinical trials and opened special clinics in Benxi, accumulating a large amount of data. Practice has proved that it is effective for neurodermatitis, psoriasis, arthritis, bursitis, folliculitis, rheumatoid arthritis, otitis media, rhinitis, adnexitis, toothache, herpes zoster, hemorrhoids, sprains, lumbar muscle strain, burns, trauma, etc.

Currently, the external medicines produced by us, such as Guyouling, athlete's foot medicine, and Fuhydrosong ointment, as well as the external preparations in major hospitals, have been widely used. The Institute of Veterinary Medicine of the Chinese Academy of Sciences uses DMSO-dissolved "Pas" to treat equine anemia and parasitic diseases. Especially in traditional Chinese medicine extract preparations, the content of useful components is increased and the efficacy is improved.

3. Application in pesticides and fertilizers

DMSO is a solvent, penetrant and synergist for pesticides and fertilizers. Foreign reports have shown that dissolving antibiotics in DMSO to treat fruit tree rot and dissolving pesticides in DMSO to kill borers in trees and fruits, and spraying 0.5‰ solution during the flowering period of soybeans can increase production by 10% to 15%. Adding 5‰ DMSO to various fertilizer aqueous solutions is more likely to cause human poisoning.

It has been used in China to treat fungal diseases of fruit trees. In experiments on plants, non-penetrating drugs and dyes were mixed into a DMSO aqueous solution and smeared on tree trunks. After 12 hours, it was found that the branches, leaves, rhizomes and fruits all contained amounts or were colored, and the results disappeared after 24 hours. This indicates that drugs and pigments dissolved in DMSO can penetrate, circulate, and be excreted through metabolism. This characteristic shows the application prospects of DMSO in agriculture, which needs to be studied in the future.