Myoglobin is low

Myoglobin is a protein located in muscles, especially in the myocardium. Low myoglobin is generally a normal phenomenon and will not affect the normal functions of the human body. But if myoglobin is too high, it means that there are certain problems in the human body, such as myocardial ischemia, myocardial damage, etc. Therefore, if the myoglobin level is found to be too high, you must go to the hospital for active treatment to avoid unexpected events.

1. Basic knowledge of myoglobin

Myoglobin is found in muscles, and is particularly abundant in the cardiac muscle. The tertiary structure of sperm whale myoglobin was elucidated by Kendrew using X-ray diffraction in 1960, which was the first described protein tertiary structure in the world. Since the tertiary structure is directly related to the biological function of the protein and the analysis of the tertiary structure is very difficult, this work has received very high praise from the academic community.

2. What causes low myoglobin?

Low myoglobin is normal, but high myoglobin may indicate a problem. If chest tightness symptoms occur at the same time, you should be alert to the possibility of myocardial ischemia, myocardial strain, etc. It is recommended to check the myocardial enzyme spectrum, electrocardiogram, etc. and provide symptomatic treatment.

3. Clinical significance of myoglobin

Determination of serum myoglobin Myoglobin can be used as the most sensitive indicator for the early diagnosis of acute myocardial infarction (AMI). However, its specificity is poor, and diseases such as skeletal muscle injury, trauma, and renal failure can all lead to its increase. Although Myo positivity cannot confirm AMI, it is an important indicator for early exclusion of AMI diagnosis. If Myo is negative, myocardial infarction is basically excluded. It can also be used to diagnose reinfarction. Combined with clinical findings, if Myo rises again, it should be considered as reinfarction or extended infarction.

Increased: seen in the early stages of acute myocardial infarction, acute muscle injury, muscular dystrophy, muscular atrophy, polymyositis, acute or chronic renal failure, severe congestive heart failure and long-term shock, etc. It may increase within 1.5 hours after myocardial infarction, but return to normal within 1 to 2 days.

(1) Increased blood levels: hypothyroidism, hyperaldosteronism, renal insufficiency, malignant hyperthermia, and after strenuous exercise, etc.

(2) Increased in urine: porphyria, hemoglobinuria, hematuria, etc.

(3) Elevated myoglobin levels in both blood and urine: seen in acute myocardial infarction, angina pectoris, cardiogenic shock, cardiomyopathy, muscle diseases (progressive muscular dystrophy, polymyositis, myasthenia gravis), etc.