Gastrin test

Gastrin is an element that affects the entire intestine. It is rich in a secretory system that can promote stomach contraction, increase gastrointestinal motility, effectively stimulate the gastrointestinal mucosa, and delay various disease problems. Therefore, it is very good for the body. However, it is important to note that gastrin must be within the normal range. Exceeding it will cause some adverse disease problems, so everyone needs to pay attention. You can understand and recognize this through some normal reference values.

How to test gastrin

Physiological significance

Gastrin is also known as gastrin.

In 1978, Rehfeld proved the existence of gastrin in human cerebrospinal fluid and certain brain tissues. Gastrin has an effect on almost the entire gastrointestinal tract. It can promote the secretory function of the gastrointestinal tract; promote the contraction of the gastric antrum and gastric body, increase the motility of the gastrointestinal tract, and promote the contraction of the pyloric sphincter. The overall comprehensive effect is to slow down gastric emptying; promote the division and proliferation of gastric and upper intestinal mucosal cells; and promote the release of insulin and calcitonin.

Gastrin can also stimulate the synthesis of DNA, RNA and protein in the gastric acid secreting gland mucosa and duodenal mucosa, thereby promoting their growth. Clinically, it can be observed that in patients who have undergone antral resection, serum gastrin levels decrease and gastric mucosal atrophy may occur; in patients with gastrinoma, serum gastrin levels are very high and are often accompanied by hyperplasia and hypertrophy of the gastric mucosa.

In recent years, it has been discovered that the buccal mucosa, tongue, esophagus, and central nervous system also contain gastrin.

Reference value

Radioimmunoassay: Fasting serum gastrin is 20~160ng/L; it increases 2~3 times after meal.

The role of gastrin

1. Stimulate the proliferation of gastric mucosal cells;

2. Stimulate parietal cells to secrete hydrochloric acid and chief cells to secrete pepsinogen;

3. Stimulate gastric antrum and intestinal motility and delay gastric emptying;

4. Stimulate the secretion of pancreatic juice, bile and intestinal juice;

5. Inhibit the contraction of the pyloric and ileocecal sphincter;