What are the precautions for using glucosamine sulfate

The drug glucosamine sulfate is a naturally occurring amino monosaccharide. It can stimulate cartilage cells, thereby controlling enzymes that damage articular cartilage. It can treat various types of arthritis in clinical practice, such as the common knee joints, spine, shoulders, hands, wrists, etc. However, it cannot be used blindly. So what are the precautions for using glucosamine sulfate?

First, what are the precautions for using glucosamine sulfate? 1. Contraindications: People who are allergic to glucosamine. 2. Use with caution is not yet clear. 3. Effects of the drug on pregnancy In animal experiments, no adverse effects of this drug on reproductive function were observed. Due to the lack of human studies, pregnant women should use it under close medical supervision after weighing the pros and cons, and should avoid use in early pregnancy. 4. Effects of the drug on lactation In animal experiments, no adverse effects of this drug on lactation were observed. Due to the lack of human studies, breastfeeding women should use it after weighing the benefits and risks.

Second, it is used to prevent and treat various types of osteoarthritis, such as osteoarthritis in the knee, hip, spine, shoulder, hand, wrist, ankle and other parts of the body. This drug can directly fight inflammation, relieve the pain symptoms of osteoarthritis, improve joint function, and prevent the progression of osteoarthritis. And there will be no adverse reactions caused by the inhibition of prostaglandins.

Third, 90% of the drug is absorbed after oral administration and is rapidly distributed to most tissues through biological barriers. It has a particular affinity for articular cartilage and can diffuse into the articular cartilage matrix and reach the chondrocytes. The blood concentration reaches its peak 4 hours after taking the drug. 1-8 hours after taking glucosamine sulfate, increasing concentrations of the drug can be detected in the liver, kidneys, stomach wall, small intestine, brain, bones, muscles and articular cartilage, and this component decreases after 24 hours. The plasma protein binding rate is less than 10%. This drug is metabolized in the liver. 10% of the oral dose is excreted in the urine, 11% is excreted in the feces, and most of the rest is excreted in the form of carbon dioxide with exhaled air. The half-life is 18 hours.

What are the precautions for using glucosamine sulfate? Inspection or monitoring should be done before, during and after medication. (1) Regularly monitor the patient's pain at rest or during exercise, ability to move freely, and walking distance. (2) Radiographic evaluation (such as joint space narrowing). (3) Routine blood biochemical examination.