Taking tuberculosis medicine causes joint pain

Patients with pulmonary tuberculosis need to take medication and strictly follow the course of anti-tuberculosis treatment. However, some tuberculosis patients may have adverse reactions such as allergies to anti-tuberculosis drugs. For example, after taking the tuberculosis drug pyrazinamide, they may experience adverse reactions such as joint pain, so you need to be vigilant. Now let me give you a detailed introduction to some adverse reactions of anti-tuberculosis drugs.

Currently, anti-tuberculosis drugs used in clinical practice are mainly divided into two categories: bactericides and bacteriostatics, also known as first-line drugs and second-line drugs. Bactericides include isoniazid, rifampicin, pyrazinamide, ethambutol, etc.; antibacterial agents include para-aminosalicylic acid, thiosemicarbazide, capreomycin, ethionamide, etc. The above drugs are effective in treating different types of tuberculosis, but their side effects cannot be ignored.

The main adverse reactions of isoniazid are peripheral neuritis, liver damage, and occasionally epileptic seizures. In general, just observe carefully. If neurological symptoms such as numbness or burning sensation in the distal limbs occur, vitamin B6 30 to 60 mg per day should be taken to improve the symptoms. While taking isoniazid, liver function should be checked regularly, at least once every 3 months, to understand the status of liver function. If the transaminase level is elevated, Chinese patent medicines for lowering enzymes, such as Schisandra chinensis preparations, should be given at the same time as liver protection treatment. There is no need to stop the medication if the transaminase level is simply elevated.

Rifampicin Gastrointestinal symptoms such as loss of appetite, nausea, vomiting and diarrhea are common drug reactions to taking rifampicin. In this case, a careful analysis should be conducted: if it is a common side effect of the drug, the medication time can be adjusted to avoid taking the drug on an empty stomach; if it is caused by an allergic reaction, the drug should be discontinued. A small number of patients may develop jaundice and elevated transaminase levels, which is common in those with overdose or chronic hepatitis. Therefore, the dosage must be strictly controlled. The drug is contraindicated in patients with a history of hepatobiliary diseases, and liver function should be checked regularly when used at regular doses.

The main adverse reaction of pyrazinamide is liver damage, which can be seen in patients with large dosages, daily doses exceeding 2 grams or long treatment courses, and is more common in the elderly. To prevent toxic reactions of the drug, the daily dose should be less than 2 grams, the course of treatment should be within 3 months, and the medication should not be used for too long. The elderly should use the drug with caution. Rare adverse reactions include increased blood uric acid and induction of joint pain, so people with gout constitution and gout patients should not use this drug. In addition, for a few people who are sensitive to sunlight, taking the medicine may cause the exposed skin to turn bright reddish brown or bronze, which will gradually recover after stopping the medicine.