How to take glucosamine to achieve effective results?

When people reach a certain age, they may experience discomfort in their legs and feet. For example, arthritis is relatively common. In addition to daily diet, exercise is also very important for the elderly. Glucosamine can be used to prevent and treat osteoarthritis of the knees, spine, shoulders, wrists, ankles, and systemic osteoarthritis. Many people don’t know much about glucosamine. How to take glucosamine to achieve its effects? Let’s take a look at it next.

1. Clinical Application

Used to prevent and treat various types of osteoarthritis, such as osteoarthritis of the knee, hip, spine, shoulder, hand, wrist and ankle joints, as well as systemic osteoarthritis.

2. Pharmacology

1. Pharmacodynamics

Through the above-mentioned effects, this drug can directly fight inflammation, relieve the pain symptoms of osteoarthritis, improve joint function, and prevent the progression of osteoarthritis. And there will be no adverse reactions caused by the inhibition of prostaglandins.

2. Pharmacokinetics

90% of this drug is absorbed orally and is rapidly distributed in most tissues through biological barriers. It has a particular affinity for articular cartilage and can diffuse into the articular cartilage matrix and reach chondrocytes. The blood concentration reaches its peak 4 hours after taking the drug. 1-8 hours after taking glucosamine sulfate, increasing concentrations of the drug can be detected in the liver, kidneys, stomach wall, small intestine, brain, bones, muscles and articular cartilage, and this component decreases after 24 hours. The plasma protein binding rate is less than 10%. This drug is metabolized in the liver. 10% of the oral dose is excreted in the urine, 11% is excreted in the feces, and most of the rest is excreted in the form of carbon dioxide with exhaled air. The half-life is 18 hours.

3. Notes

1. Contraindications: People who are allergic to glucosamine.

2. Use with caution is not yet clear.

3. Effects of drugs on pregnancy

In animal experiments, no adverse effects of this drug on reproductive function were observed. Due to the lack of human studies, pregnant women should use it under close medical supervision after weighing the pros and cons, and should avoid use in early pregnancy.

4. Effects of the drug on lactation In animal experiments, no adverse effects of this drug on lactation were observed. Due to the lack of human studies, breastfeeding women should use it after weighing the benefits and risks.

5. Check or monitor before, during and after medication

(1) Regularly monitor the patient's pain at rest or during exercise, ability to move freely, and walking distance.

(2) Radiographic evaluation (such as joint space narrowing).

(3) Routine blood biochemistry examination.

4. Adverse Reactions

1. Mild and transient gastrointestinal symptoms such as nausea, constipation, abdominal distension and diarrhea are rare.

2. Some patients may experience allergic reactions, including rash, itching and skin erythema.

3. Mild drowsiness may occur occasionally.

5. [Foreign adverse reactions reference]

1. Peripheral edema and tachycardia have been reported in the cardiovascular system.

2. Headache and insomnia may occur in the central nervous system.

3. Skin erythema and itching are rare; injection site pain is rare.