What are the side effects of taking tacrolimus

The liver and kidneys are extremely important physiological organs of the human body, but many times we fail to protect them well, or because of some genetic factors, the liver and kidneys suffer from serious diseases, and ultimately liver and kidney transplants are needed to prolong life. In this case, of course, drugs are needed, and tacrolimus is one of them. So, what are the side effects of taking tacrolimus?

In recent years, it has been marketed in 14 countries including Japan and the United States as a first-line drug for liver and kidney transplantation. Clinical experiments have shown that it has a good therapeutic effect in heart, lung, intestinal, bone marrow and other transplants. At the same time, FK506 also plays an active role in the treatment of autoimmune diseases such as atopic dermatitis (AD), systemic lupus erythematosus (SLE), and autoimmune eye diseases.

Because most patients have serious illnesses and take many other medications at the same time, it is often difficult to identify adverse reactions associated with immunosuppressive drugs. There is evidence that many of the following adverse drug reactions are reversible and may improve with dose reduction. The frequency of adverse reactions is significantly lower with oral administration compared to intravenous administration.

The following adverse drug reactions are organized according to body system and their frequency of occurrence. Cardiovascular System - Frequent: hypertension. Occasionally: angina pectoris, palpitations, effusion (e.g. pericardial effusion, pleural effusion). Rare: Hypotension including shock, ECG abnormalities, arrhythmias, atrial/ventricular fibrillation and cardiac arrest, thrombophlebitis, bleeding (e.g., gastrointestinal, cerebral), heart failure, cardiomegaly, bradycardia.