What is the reason for elevated glutamyl transpeptidase

Glutamyl transpeptidase is an indicator of clinical examination. First, let's understand what glutamyl transpeptidase is. This is a common enzyme in the human body and is distributed in many human tissues, among which the kidneys and liver are more distributed. When glutamyl transpeptidase increases, it means that the liver function of the person has declined, which will increase the permeability of the liver cell membrane and cause great harm to health. Acute viral hepatitis, chronic hepatitis, alcoholic liver, fatty liver, and even liver cancer often occur. In addition, in addition to liver disease, when glutamyl transpeptidase increases, you should also be alert to myocardial infarction, acute pancreatitis and other diseases.

First, acute viral hepatitis

When suffering from "acute viral hepatitis", the liver cells adjacent to the necrotic area synthesize hyperactive enzymes, which causes an increase in serum glutamyl transpeptidase. This factor is also the most common and the one that cannot be ignored.

Second, chronic active hepatitis

In chronic active "hepatitis", glutamyl transpeptidase is often 1-2 times higher than normal. If it remains elevated for a long time, there may be a tendency towards liver necrosis.

Third, intrahepatic or extrahepatic bile duct obstruction

Due to the obstruction of glutamyl transpeptidase excretion, it will reflux into the blood with bile, resulting in high glutamyl transpeptidase levels.

4. Alcoholic hepatitis

The level of glutamyl transpeptidase is almost always elevated in patients with alcoholic hepatitis and alcoholic cirrhosis, becoming an important feature of "alcoholic liver disease".

5. Metastatic Liver Cancer

In patients with primary or "metastatic liver cancer", glutamyl transpeptidase levels are mostly moderately or highly increased, which can be several times or even dozens of times higher than normal.

6. Biliary cirrhosis

In the early stages of primary or secondary "biliary cirrhosis", elevated glutamyl transpeptidase levels may also occur.

7. Fatty liver

Patients with "fatty liver" may also experience elevated glutamyl transpeptidase levels, but in general, in cases of nutritional fatty liver, the serum glutamyl transpeptidase activity is usually no more than twice the normal value.

If the glutamyl transpeptidase level is high, don't panic first, because it may be caused by physiological reasons. Friends who have glutamyl transpeptidase should go to a regular "liver disease" specialist hospital for a reexamination one week later to ensure the accuracy of the test results. If the glutamyl transpeptidase is still higher than the normal value, a detailed examination is recommended.