What are the side effects of oxaliplatin?

Injection of oxaliplatin may cause anemia, leukopenia, thrombocytopenia and other symptoms. Injection of oxaliplatin alone may also cause digestive problems, such as nausea, vomiting, and diarrhea.

1. Hematopoietic system: Oxaliplatin (oxaliplatin for injection) has certain blood toxicity. When used alone, the following adverse reactions may occur: anemia, leukopenia, granulocytopenia, and thrombocytopenia, sometimes reaching grade 3 or 4. When used in combination with 5-fluorouracil, hematologic toxicities such as neutropenia and thrombocytopenia are increased;

2. Digestive system: Oxaliplatin (oxaliplatin for injection) used alone can cause nausea, vomiting, and diarrhea. These symptoms are sometimes severe. These side effects are significantly increased when combined with 5-fluorouracil. Prophylactic and/or therapeutic antiemetic medication is recommended;

3. Nervous system: Peripheral sensory neuropathy characterized by peripheral neuritis. Sometimes it may be accompanied by spasm and sensory disturbances around the mouth, upper respiratory tract, and upper digestive tract. It may even resemble the clinical manifestations of laryngeal spasm without any anatomical basis. It can recover on its own without any sequelae. These symptoms are often triggered or aggravated by colds. Paresthesia can be alleviated during the treatment rest period, but when the cumulative dose is greater than 800 mg/m2 (6 cycles), it may cause permanent paresthesia and functional impairment. Within a few months after termination of treatment, neurotoxicity can be reduced or disappeared in more than 3/4 of patients. When reversible paresthesias occur, there is no need to adjust the next dose of oxaliplatin (Oxaliplatin for injection). Dosage adjustments should be based on the duration and severity of observed neurological symptoms. When paresthesia persists between two courses of treatment, painful paresthesia and/or functional impairment begin to occur, the dose of oxaliplatin (injection) should be reduced by 25% (or 100 mg/m2). If symptoms persist or worsen after dose adjustment, treatment should be discontinued. After the symptoms have completely or partially disappeared, it is still possible to use the full dose or a reduced dose, and the decision should be made based on the physician's judgment.