What is the normal value of aspartate aminotransferase? What is the clinical significance?

Many people are not clear about what aspartate aminotransferase is. Clinically, aspartate aminotransferase is distributed in various tissues of the body, and the content of aspartate aminotransferase in serum is also measured by a certain numerical value. Normal aspartate aminotransferase values ​​indicate normal physical condition, but if the aspartate aminotransferase is too high, you should be careful about whether there is a problem with liver function. It is recommended to check and treat as soon as possible. Aspartate aminotransferase has many clinical significances. What is the normal value of aspartate aminotransferase?

1. Normal value of aspartate aminotransferase

The normal value is between 5-40u/l. Generally, if it exceeds 40, it means that there is abnormality in liver function and a detailed examination is needed. When the aspartate aminotransferase level in a hepatitis B patient is high, it indicates that the liver function is impaired. High aspartate aminotransferase is a sign that the hepatitis B patient needs treatment. Aspartate aminotransferase is mainly distributed in the liver cells. When the liver cells are damaged, the aminotransferase will be released into the blood, so the transaminase test result will be high. The degree of elevation of aspartate aminotransferase is consistent with the degree of liver cell damage. If not treated promptly, the virus will slowly cause massive liver cell death, the disease will gradually worsen, and eventually develop into liver cancer.

2. Hepatitis

In acute viral hepatitis, serum AST activity may increase significantly, generally 10 to 30 times the upper limit of the normal reference value, and not higher than the serum ALT activity measured at the same time. When the increase in serum AST activity continues to exceed ALT activity, it indicates that the hepatitis lesions are chronic and progressive. Cirrhosis, liver cancer, hepatic congestion, and biliary obstruction may be normal or slightly elevated.

3. Myocardial infarction

AST is most abundant in myocardial cells. Serum AST activity increases during myocardial infarction. Serum AST activity begins to rise 6 to 8 hours after onset and reaches a peak at 18 to 24 hours. The peak AST activity is proportional to the size of the infarct. If no new infarction occurs, the enzyme activity returns to normal after 4 to 5 days; if it rises again, it indicates that the infarction focus has expanded or a new infarction has occurred. Myositis, crush syndrome, muscle injury, nephritis and pneumonia can also cause increased serum AST activity. Combined with the AST/ALT ratio, further judgments can be made on liver disease. When the ratio is less than 1, it is usually mild liver damage and some inflammatory diseases. When >1, especially >2, it indicates severe liver disease of the predominantly necrotic type.