What is the effect of deacetylase?

The norepinephrine effect mentioned here mainly refers to the effect and effect of norepinephrine drugs on the body. Generally, norepinephrine mainly enhances the contractility of the myocardium, which can be beneficial to the recovery of shock patients. When using drugs such as norepinephrine, you need to be informed by a regular hospital before taking them. Blindly taking them can easily cause excessive effects on the body.

Norepinephrine has a strong excitatory effect on α receptors and a weaker effect on β receptors. It causes constriction of small arteries and small veins throughout the body (but dilation of coronary arteries), increases peripheral resistance, rises blood pressure, and increases perfusion of important organs such as the heart and brain. Small doses of intravenous drip can increase myocardial contractility and cardiac output, restore myocardial metabolism and function, and facilitate recovery from shock.

Pharmacological effects of norepinephrine

Norepinephrine has a strong excitatory effect on α receptors and a weaker effect on β receptors. It causes constriction of small arteries and small veins throughout the body (but dilation of coronary arteries), increases peripheral resistance, rises blood pressure, and increases perfusion of important organs such as the heart and brain. Small doses of intravenous drip can increase myocardial contractility and cardiac output, restore myocardial metabolism and function, and facilitate recovery from shock.

Pharmacokinetics of norepinephrine

After oral administration of norepinephrine, the gastric mucosal vasoconstriction occurs, absorption is very low, and it is easily destroyed by alkaline intestinal fluid, so oral administration is ineffective. Subcutaneous or intramuscular injection causes severe vasoconstriction, slow absorption, and can easily lead to local tissue necrosis. After intravenous injection, the effect only lasts for a few minutes due to rapid metabolism in the body. Therefore, it is generally only administered by intravenous drip. After norepinephrine enters the body, most of it is actively taken up by the norepinephrine adrenergic nerve endings. When the blood drug concentration increases, it can also be taken up and metabolized by non-neural tissues, and finally form 4-hydroxy-3-methoxymandelic acid, which is mainly excreted through the kidneys in the form of metabolites, with only a trace amount of the original drug.