What is the best way to treat non-gonococcal urethritis?

Non-gonococcal urethritis is a common disease in life. The early symptoms are not obvious, so it is often ignored by people. Once it attracts people's attention, it means that the disease has been present for some time. So what is the best way to treat non-gonococcal urethritis? In fact, there are ten treatment methods, and only by choosing the treatment method based on specific symptoms can the treatment effect be best.

1. During the acute active phase, especially when important organs are affected, you should rest in bed.

2. Local treatment: For oral and pharyngeal ulcers, glucocorticoid paste, patch or tin powder can be used; for genital ulcers, first clean with potassium permanganate solution and then apply antibiotic ointment; for uveitis, mydriatic eye drops can be used, and then 0.5% cortisone eye drops, 3 to 4 times/d, for 4 to 5 days; when the inflammation is severe, 5 mg of dexamethasone can be injected under the conjunctiva, 1 to 2 times, to reduce inflammatory exudation.

3. Surgical treatment: Surgical complications such as intestinal perforation can be treated with surgery, but the prognosis is poor.

4. Glucocorticoids can relieve symptoms and are suitable for short-term use. The dosage depends on the severity of the symptoms of the affected organs. If the symptoms are severe, a larger dose is recommended. Prednisone is generally taken at 30 to 60 mg/d. The dosage is reduced after it becomes effective. The course of treatment should not exceed 3 months.

5. Cyclosporine A has the same effect as chlorambucil. The dose is 5 mg/(kgd), and after 2 weeks of maintenance treatment, the dose is gradually reduced. This drug is contraindicated in the treatment of optic atrophy, ocular muscle degeneration, decreased liver and kidney function, and neuro-Behcet's disease accompanied by hypertension.

6. FK506 is suitable for refractory uveitis, with a dosage of 0.1-0.15 mg/(kgd). Side effects include renal impairment, neurological and gastrointestinal symptoms.

7. Immunomodulators that can be tried include levamisole, transfer factor and interferon.

8. Take 60 mg/d of Tripterygium wilfordii glycoside tablets orally in 3 doses for 2 to 3 months.

9. Chlorambucil is suitable for uveitis, oral ulcers and prevention of recurrence of neurobehcet's disease. The dosage is 50-100 mg/d, orally. After the acute inflammation is relieved, the dosage is gradually reduced to 2-4 mg/d. Peripheral blood counts should be monitored during medication. If white blood cells are <3.0×109/L, medication should be discontinued promptly. Other side effects include carcinogenesis, infertility, amenorrhea and hair loss.

10. Cyclophosphamide pulse therapy is suitable for anterior or posterior uveitis, retinal vasculitis and optic neuritis. The dose is 1g/m2 body surface area, intravenous drip, or 0.5g/m2 body surface area, plus prednisone 0.5mg/(ksd), with similar therapeutic effects.

If non-gonococcal urethritis is not treated thoroughly, it may often be complicated by prostatitis, epididymitis, infertility, etc. Therefore, in order to completely cure the disease, patients must take urethral or cervical secretions for chlamydia and mycoplasma culture before and after taking the medicine. Positive patients must use sufficient and effective anti-gonococcal antibiotics while also taking drugs effective against chlamydia and mycoplasma until the chlamydia and mycoplasma culture is negative.