What is the normal value of creatinine

Creatinine value refers to the normal value of blood creatinine. When the creatinine value is too high or too low, there may be a problem with kidney function. If you find yourself feeling weak and edematous in recent time, you should go to the hospital as soon as possible to check the normal value of creatinine. So what is the normal value of creatinine? How much is normal?

Serum creatinine

The normal value of blood creatinine varies from hospital to hospital. Generally speaking, the normal value of blood creatinine is 44-133umol/L. When blood creatinine exceeds 133umol/L, it means that the kidneys are damaged and renal insufficiency or renal failure has occurred. (Above 133umol/L is the inflammatory damage stage, 186umol/L is the renal function damage stage, 451umol/L is the renal failure stage, and blood creatinine values ​​exceeding 707umol/L indicate that it has reached the late stage (uremia).

Normal value of serum creatinine (SCr):

Male: 54-106 μmol/L (0.6-1.2 mg/dL);

For women: 44-97 μM/L (0.5-1.1 mg/dL).

Children: 24.9~69.7umol/L.

Too high reason

Changes in serum creatinine concentration are mainly determined by the filtration capacity of the glomeruli (glomerular filtration rate). As filtration capacity decreases, creatinine concentration increases. A serum creatinine level higher than normal usually means kidney damage. Serum creatinine can more accurately reflect the extent of renal parenchymal damage, but it is not a sensitive indicator. Because blood creatinine will only increase significantly when the glomerular filtration rate drops to one-third of that of a normal person.

The reason for low blood creatinine is that after the kidneys are invaded by various causes, the damaged kidney intrinsic cells first undergo phenotypic transformation, forming pathological changes, stimulating the kidney's fibroblasts to transform into myofibroblasts, and at the same time invade and stimulate the inherent normal renal tissue, causing the same lesions, thus forming a process of expansion and stimulation of the kidney from point to surface, from local to overall, and thus entering the organic damage period (i.e., renal function damage period). At this time, due to the continuous damage to the kidneys, their function of excreting waste is reduced, resulting in the accumulation of toxins such as creatinine in the body, resulting in increased creatinine and urea nitrogen in the blood, decreased creatinine in the urine, and decreased renal filtration rate. At the same time, patients will also have other physical symptoms such as high blood pressure and severe edema.