What are the effects of aminophylline

Aminophylline is a drug used to treat bronchial asthma. It is often used and has good efficacy. However, it should be noted that when using these drugs, you must follow the doctor's guidance and advice and never use them blindly to avoid causing more adverse effects.

1. Aminophylline is an important drug for the treatment of bronchial asthma . Intravenous injection of aminophylline has a rapid and effective antiasthmatic effect and is commonly used in clinical practice. However, it has a small safety margin, a narrow therapeutic index, and large individual differences in the rate of elimination from the body. If used improperly, it can easily cause serious toxic side effects and even be life-threatening. Its pharmacological effect mainly comes from theophylline, and ethylenediamine enhances its water solubility.

2. Aminophylline has a direct relaxant effect on respiratory smooth muscles . Its mechanism of action is relatively complex. In the past, it was believed that it increased the intracellular cAMP content by inhibiting phosphodiesterase.

3. Recent experiments have shown that the bronchial dilation effect of theophylline is partly due to the release of endogenous adrenaline and norepinephrine. In addition, theophylline is a purine receptor blocker that blocks the airway contraction of adenine. Theacrine can enhance the contraction force of the diaphragm, especially during diaphragm contraction, the effect is more significant and helps improve respiratory function.