What are the causes of low platelets

If the platelet content in the human body is low, it will pose a threat to health. Because the function of platelets in daily life is to coagulate blood, if there is a small wound on the body and bleeding, the platelets will stop the bleeding from the wound.

Causes

1. Drugs that cause low bone marrow regeneration or disorder accompanied by pancytopenia. Chemical substances and drugs that can easily cause bone marrow hypoplasia at certain doses:

①Benzene, xylene, etc. ②Alkylating agents: such as nitrogen mustard, cyclophosphamide, phenylpropionate mustard, etc. ③Antimetabolites: such as cytarabine, mercaptopurine, etc. ④Anti-cancer antibiotics: such as doxorubicin, adriamycin, etc. ⑤Others: such as organic arsenic, etc.

2. Drugs that can cause bone marrow aplasia or hypoplasia: such as chloramphenicol, sulfonamides, penicillin, streptomycin, linezolid, Xinqing No. 1, trimethadione, phenytoin sodium, ethosuximide, antithyroid drugs (such as thiouracil, propylthiouracil, thyroxine), diabetes drugs (such as tolbutamide, chlorbutamide, chlorpropamide, etc.), phenylbutazone, indomethacin, tranquilizers and sedatives (tranquilization, chlordiazepoxide, chlorpromazine, etc.), gold preparations, hair dyes, promethazine, chlorpheniramine, acetazolamide, etc.

3. Drugs that selectively inhibit the production of platelets by megakaryocytes: such as chlorothiazide, estrogens, ethanol, tolbutamide, and ristocetin.

4. It is usually caused by antibodies (biochemical substances with protective effects) formed by the body attacking its own platelets. Certain acute infections are the root cause of this disease. Too much blood transfusion in a short period of time (such as during major surgery), or abnormal bleeding and clotting may cause thrombocytopenia.