What are the clinical manifestations of fever with thrombocytopenia syndrome

Fever with thrombocytopenia syndrome is a common sign caused by low platelets. For this feature, the accompanying symptoms are also relatively obvious. Generally speaking, symptoms such as general discomfort, headache, vomiting, etc. will appear, and you should pay attention at this time.

Clinical manifestations

The incubation period is generally 7-14 days (average 9 days). The disease starts acutely, with the main symptoms being fever (mostly persistent high fever, up to 40°C or above), general discomfort, fatigue, headache, muscle aches, as well as nausea, vomiting, anorexia, diarrhea, etc. Some patients also have cough and sore throat. Physical examination may reveal apathy, relatively slow pulse, and a few patients may have superficial lymphadenopathy and rash. It may be accompanied by damage to the functions of multiple organs such as the heart, liver, and kidneys, and corresponding clinical manifestations. Severe patients may have interstitial pneumonia, pulmonary edema, acute respiratory distress syndrome, and secondary bacterial, viral, and fungal infections. A small number of patients may experience bleeding in the skin, lungs, and digestive tract due to severe thrombocytopenia and abnormal coagulation function. If not treated in time, they may die from multiple organ failure such as respiratory failure, acute renal failure, and disseminated intravascular coagulation. Elderly patients, immunocompromised patients and those receiving hormone treatment are often in critical condition after being infected with this disease.

Laboratory tests

Laboratory examination of peripheral blood showed decreased white blood cells and platelets, and increased atypical lymphocytes. Patients with combined organ damage may have abnormal heart, liver, and kidney function tests. Etiology and serology tests were positive. in:

Blood routine test: Leukopenia and thrombocytopenia can serve as important clues for early diagnosis. In the first week of the disease, patients will show leukocytopenia, mostly 1.0-3.0×109/L; platelet decrease, mostly 30-50×109/L. Atypical lymphocytes may be seen.

Urinalysis: proteinuria, hematuria, tubular urine.

Blood biochemical examination: abnormal liver and kidney function; elevated myocardial enzyme spectrum; a small number of patients have elevated blood amylase, urine amylase and blood sugar.

Some patients have prolonged prothrombin time and elevated fibrinogen degradation products. There may be blood electrolyte disorders, such as low sodium, low chloride, low calcium, etc. A small number of patients also have decreased bilirubin and serum protein.