Pathogenesis of post-hepatic jaundice

I believe everyone must be curious about the pathogenesis of post-hepatic jaundice. The occurrence of jaundice is undoubtedly very scary. When its symptoms suddenly appear, it brings a visual shock to many people. This is not intentionally said to be serious to scare people. This disease brings a double blow to the patient both physically and mentally. Let us now explore the pathogenesis of post-hepatic jaundice.

(I) Excessive bilirubin formation

When excessive bilirubin is formed in the body and exceeds the liver's ability to process it, a large amount of unconjugated bilirubin accumulates in the blood and jaundice occurs. The causes of excessive formation of unconjugated bilirubin include two major categories: hemolytic and non-hemolytic. When massive hemolysis is caused by any reason clinically, the large amount of hemoglobin released by the destruction of red blood cells becomes the source of bilirubin. Excessive formation of non-hemolytic bilirubin is often seen in ineffective hematopoiesis resulting in excessive bilirubin production.

2. Decreased ability of liver cells to process bilirubin

These include: ① Impairment in the uptake of bilirubin by hepatocytes; ② Impairment in the binding of bilirubin by hepatocytes (reduced activity of glucuronyltransferase in hepatocytes); ③ Impairment in the excretion of bilirubin by hepatocytes (intrahepatic cholestasis, alcoholic hepatitis, etc.).

(III) Impairment of bilirubin excretion outside the liver, which causes reflux into the blood and causes jaundice

The causes of physiological jaundice in newborns are as follows: ① The activity of glucuronyl transferase in the liver cells of newborns is not high; ② Bilirubin is produced in large quantities in the bodies of newborns; ③ The liver cells of newborns lack Y protein, so their ability to absorb bilirubin is also worse than that of adults. These may all lead to physiological jaundice in newborns. Jaundice refers to the phenomenon of yellowing of tissues such as the skin, sclera and mucous membranes caused by hyperbilirubinemia. Normal human serum bilirubin is less than 1 mg/dl (10 mg/L), of which unconjugated bilirubin accounts for 80%. When bilirubin exceeds the normal range but is within 2 mg/dl, it is difficult to detect with the naked eye and is called latent jaundice. If the bilirubin exceeds 2 mg/dl (can be as high as 7-8 mg/dl), it is overt jaundice.

From the above we can know the pathogenesis of post-hepatic jaundice. If you have relatives or friends who suffer from post-hepatic jaundice, please do not be overly afraid or resistant, do not have too heavy psychological burden, actively cooperate with the doctor's treatment, and protecting your health is the most important thing. Bravely treat post-hepatic jaundice and regain a healthy body as soon as possible.