How to treat low neutrophil count

How to treat low neutrophil count? This issue is of concern to many patients with low neutrophil counts. The so-called neutrophils are actually a type of cell in our blood. If the content of this type of cell decreases, it means that there is a problem with our body and treatment is required. So, what is the best way to treat a low neutrophil count?

1. Treatment to increase neutrophil count

(1) Leukopoiesis-stimulating drugs: There are many drugs currently used in clinical practice, such as vitamin B6, vitamin B4, leukoplakia, inosine, deoxyribonucleotides, androgens, lithium carbonate, etc. However, they all lack definite and lasting therapeutic effects. Therefore, patients with initial treatment can choose 1 to 2 types and change one group every 4 to 6 weeks until they are effective. If there is no effect for several consecutive months, there is no need to continue using them.

(2) Immunosuppressive drug treatment: such as glucocorticoids, azathioprine, cyclophosphamide, high-dose human immunoglobulin infusion, etc., are effective for some patients, such as those with positive anti-neutrophil antibodies or bone marrow failure mediated by cytotoxic T cells.

(3) Colony stimulating factor therapy: mainly filgrastim (rhG-CSF) and rhGM-CSF. Filgrastim (rhG-CSF) for the treatment of severe chronic neutropenia (absolute neutrophil count < 0.5 × 109/L)

Treatment of patients with infectious neutropenia If the neutropenic patient has only fever and no sepsis, he or she can generally be treated as an outpatient to avoid secondary infection in the hospital. When severe neutropenia patients (especially those with agranulocytosis) develop fever, they should be treated as medical emergency patients and immediately admitted to the hospital for treatment. If conditions permit, they should be reversely isolated. After bacterial culture examination of the skin, throat, blood, urine, stool and other parts, empirical broad-spectrum antibiotic treatment was immediately given.

If the pathogen is clearly identified in the patient, targeted narrow-spectrum antibiotics will be used based on drug sensitivity tests. If no pathogen is found but the condition is controlled after treatment, oral antibiotics should continue to be given for 7 to 14 days after the condition is cured. If no pathogen is found and the patient's condition does not improve after 3 days of the above treatment, empirical antibiotic treatment can be discontinued for patients with mild symptoms, and pathogen culture can be performed again. If the patient's condition is severe, antifungal drugs such as amphotericin B should be added to the original treatment. For patients with severe infections, neutrophil transfusion can also be given. Since neutrophils have a short survival time in peripheral blood and tissues, it must be given at least once a day for 3 consecutive days to be effective.

After knowing how to treat low neutrophil counts, it is recommended that all patients cooperate with their doctors during treatment. Also, because low neutrophil counts are related to some infections, patients must pay special attention to their diet and hygiene habits during treatment to avoid reinfection.