Childhood osteosarcoma survival rate

The survival rate of childhood osteosarcoma is affected by many factors, and early diagnosis and comprehensive treatment are the key. Through comprehensive treatment of surgery, chemotherapy and radiotherapy, the five-year survival rate can reach 60%-70%. Genetics, environment, physiological factors and trauma may affect the development of the disease and the treatment effect.

1. Genetic factors

Osteosarcoma in children is associated with inherited gene mutations. For example, TP53 gene mutations may increase the risk of the disease. Children with a family history of osteosarcoma need regular physical examinations to detect abnormalities early. Genetic testing can help identify high-risk groups and take preventive measures in advance.

2. Environmental factors

Long-term exposure to radiation or chemicals may increase the risk of osteosarcoma. Preventing children from coming into contact with harmful substances, such as benzene and formaldehyde, is an important preventive measure. The air and water quality in the living environment also need to be paid attention to to ensure health and safety.

3. Physiological factors

Adolescence is a high-risk period for osteosarcoma, which may be related to rapid bone growth. Maintaining a balanced diet and taking in enough calcium and vitamin D can help maintain bone health. Moderate exercise such as swimming and running can also enhance physical fitness and reduce the risk of disease.

4. Trauma

Severe trauma may lead to abnormal proliferation of local tissues and increase the incidence of osteosarcoma. Prevent children from participating in high-risk activities, such as extreme sports, to reduce accidental injuries. Seek medical attention promptly after trauma to prevent complications.

5. Pathological factors

Early symptoms of osteosarcoma include local pain and swelling, which can be easily mistaken for growing pains. If you experience persistent pain or unexplained lumps, you should seek medical attention immediately. Imaging tests such as X-rays, MRI, and CT can help with early diagnosis.

6. Treatment methods

Surgery is the main treatment for osteosarcoma, including tumor resection and limb-preserving surgery. Common chemotherapy drugs include methotrexate, doxorubicin and cisplatin, which can effectively control the spread of tumors. Radiotherapy can be used as an adjuvant treatment to reduce the risk of recurrence.

7. Rehabilitation and nursing

Postoperative rehabilitation includes physical therapy and functional exercises to help restore limb function. Psychological support is particularly important for children, and parents and doctors should give encouragement and care. Regular follow-up examinations should be conducted to monitor changes in the condition and adjust the treatment plan in a timely manner.

The survival rate of childhood osteosarcoma is closely related to early diagnosis and comprehensive treatment. The survival rate can be improved through genetic screening, environmental improvement, healthy lifestyle and timely treatment. Parents need to pay attention to their children's physical changes, seek medical treatment in time if problems are found, and actively cooperate with treatment to achieve the best prognosis.