Insulin and obesity

Insulin is a relatively common drug and is also a drug that has a good effect in treating and controlling symptoms such as diabetes. Of course, if insulin is taken for a long time, it is likely to cause obesity in patients. Of course, when this problem occurs, certain countermeasures need to be taken in a timely manner! Here I will introduce to you how to deal with obesity caused by insulin!

1. Improve your lifestyle

Limit daily calorie intake and adhere to a lifestyle intervention based on a healthy diet (low-energy, high-fiber food) and exercise (brisk walking for more than 40 minutes a day, ≥ 5 days a week).

2. Rational use of hypoglycemic drugs

1. For patients with type 1 diabetes, adjust the insulin dosage to the appropriate range; you can also take metformin to reduce the amount of insulin.

2. For patients with type 2 diabetes, especially obese patients, insulin sensitizers should be used actively, with metformin + thiazolidinediones (TZDs) being the first choice.

3. For obese patients with type 2 diabetes, insulin sensitizer + insulin secretagogue, insulin sensitizer + α-glucosidase inhibitor, insulin sensitizer + insulin glucagon-like peptide-1 (GLP-1) receptor agonist + insulin are all good combinations. GLP-1 receptor agonists help reduce weight gain after insulin therapy.

4. Insulin should be selected from human gene recombinant insulin or insulin analogs with high purity and low antigenicity, and the lowest dose should be used to achieve the best blood sugar-lowering effect.

3. Actively use lipid-lowering drugs

For different types of dyslipidemia, lipid-lowering drugs such as statins or fibrates can be used. As long as the main indicators of blood lipids can be controlled within the target range, the cardiovascular risk will be significantly reduced. The 2007 edition of the "Guidelines for the Prevention and Treatment of Dyslipidemia in Chinese Adults" defines coronary heart disease combined with diabetes as an extremely high-risk category and diabetes as a high-risk category, with LDL-C control levels of <80 mg/dl and <100 mg/dl, respectively.