What are the mid-stage symptoms of lymphoma and what is the treatment effect?

What are the mid-stage symptoms of lymphoma? How is the treatment effect?

The main symptoms of late-stage lymphoma:

Bones: Clinical manifestations include local bone pain and secondary nerve tenderness. Skin: Nonspecific damage commonly includes pruritus and prurigo. Pruritus is more common in Hodgkin's disease, accounting for 85%, and may appear before other rashes. Severe sweat retention can also be seen occasionally. Tonsils and oral, nasal, and pharyngeal lymphomas invading the oral, nasopharyngeal region may clinically cause dysphagia, nasal congestion, and epistaxis.

Gastrointestinal tract: Lymphoma lesions in extranodal lymphoid tissue are most common in the gastrointestinal tract, accounting for about 25% of non-Hodgkin's lymphoma and only 2% of Hodgkin's disease. Clinical manifestations include loss of appetite, abdominal pain, diarrhea, intestinal obstruction and bleeding. The most common site of invasion is the small intestine, of which more than half are the ileum, followed by the stomach. Primary small intestinal tumors are most common in non-Hodgkin's lymphoma, with malabsorption syndrome or steatorrhea as the main clinical manifestations, and lesions often occur in the jejunum. Gastrointestinal lesions generally spread from the retroperitoneal lymph nodes through the mesenteric lymphatic vessels.

Hepatobiliary: Invasion of the liver parenchyma may cause pain in the liver area. Jaundice may occur when diffuse infiltration of the liver or enlarged lymph nodes are detected by pressure on the common bile duct. About 15% of patients with Hodgkin's disease involving the liver have jaundice; Others: Lymphoma may also infiltrate the pancreas and cause malabsorption syndrome. Mediastinal lymphoma metastasizes to the pericardium and may cause local tumors.