What is the significance of PSA in diagnosing prostate cancer?

PSA is an enzyme produced by the prostate gland and is specific to prostate tissue. It is divided into serum free PSA and total PSA. It has a high prediction rate for prostate cancer and can improve the diagnosis rate of localized prostate cancer and increase the chances of radical treatment of prostate cancer. PSA is of great significance for the diagnosis of prostate cancer, especially for more limited and early prostate cancer.

Early diagnosis and early treatment give patients a greater chance of survival and survival time. In the past few decades, in addition to the dramatic changes in the incidence and mortality of prostate cancer, the clinical staging of newly diagnosed prostate cancer patients has also changed substantially in a more favorable direction. This change in clinical staging is mainly due to the application of PSA screening. Since PSA screening was applied clinically, the proportion of localized prostate cancer has increased, while the proportion of advanced prostate cancer has decreased.

The application of PSA has also led to a significant downward trend in the pathological stage of prostate cancer. The increase in the proportion of localized prostate cancer found during radical prostatectomy proves this. PSA screening can cause changes in clinical and pathological staging, and the mortality rate of the population with widespread screening has a downward trend. These indirectly prove that screening is beneficial.