How to pathologically grade prostate cancer

The grading of prostate cancer is a very important aspect that we need to pay attention to during the treatment of prostate cancer. Many people forget the grading of prostate cancer during the treatment process, which may lead to some unexpected situations during the treatment. So, how to pathologically grade prostate cancer?

The Gleason scoring system is currently the most commonly used pathological grading system for prostate cancer.

Grading Standard:

Gleason 1: Cancer is extremely rare. It has clear borders, expands in size, and hardly invades the stroma. The cancer acini are simple, mostly round, medium-sized, and closely arranged. The cytoplasm is very similar to that of benign epithelial cells.

Gleason 2: Cancer is rare and mostly occurs in the transitional zone of the prostate. The border of the cancer is not very clear. The cancer alveoli are separated by the matrix and are simple round in shape. They can be of different sizes and irregular, and are loosely arranged.

Gleason 3: The most common type of cancer, mostly occurring in the peripheral area of ​​the prostate. The most important feature is invasive growth. The cancer acini vary in size and shape, with large and red nucleoli and alkaline staining in the cytoplasm.

Gleason 4: The tumor is poorly differentiated and grows invasively. The cancer alveoli are irregularly fused together to form tiny papillary or cribriform shapes. The nucleoli are large and red, and the cytoplasm may be alkaline or gray.

Gleason 5: The tumor is extremely poorly differentiated, with regular circular or irregular borders, accompanied by invasive growth, a lamellar single cell type or a comedone type of cancer, accompanied by necrosis, cancer cell nuclei are large, the nucleoli are large and red, and cytoplasmic staining may vary.

The above are some of the things we should know when we are grading prostate cancer. The treatment of prostate cancer is based on correct dialectics. The effect of our treatment is also determined by this. I hope everyone can understand it carefully.