What are the commonly used drugs after breast cancer bone metastasis? These drugs are essential

What are the commonly used drugs after breast cancer bone metastasis? Everyone knows that breast cancer is a terrible malignant tumor, and in the later stage, it will metastasize. The common metastasis target is bone metastasis. So how should it be treated in such a situation? What drugs are there?

What are bone metastases?

Bones are a common site of metastasis. Bone metastasis, or "bone metastasis," occurs when cancer cells move from the primary tumor to the bone. Prostate cancer, breast cancer, and lung cancer are most likely to spread to the bones. However, other cancers are not excluded. Bone metastasis does not start in the bones, but moves there from the site of the primary tumor. Primary bone cancer, on the other hand, is a rare cancer where the primary tumor actually starts in the bone. Therefore, bone cancer and bone metastasis are not the same.

As an example, take a man with prostate cancer. Prostate cancer cells from the primary tumor can break apart and enter the bloodstream. Once in the bloodstream, the cancer cells can then travel to the bone and form a new (secondary) tumor. It is important to remember that this secondary tumor is made up of abnormal prostate cancer cells, not abnormal bone cells. The result of this process is called prostate cancer that has metastasized to the bone, or metastatic prostate cancer. This is also called bone metastasis.

When cancer cells spread to the bones, they can cause changes in the bones. The process by which parts of the bone are damaged is called osteolysis. Often, small holes form as a result of the breakdown of the bones. These holes in the bones are called osteolytic lesions or lytic lesions. Lytic lesions can weaken the bones and increase the risk of fractures or other problems. People with bone metastases also often have pain from the lesions.

Bone metastasis is common in cancer patients. It's important to understand some common symptoms, how bone metastasis is diagnosed, and what treatment options are currently available. Pay attention to your own body and share any concerns you may have with your doctor.

Bone foundation

Bones have many functions. They support us, allow us to move, and protect our internal organs. Bones store and release minerals that are important for our body's functions. Our blood cells are also made and stored in bones.

The outer layer of bone is called the cortex. It provides most of the support for our skeleton. It is also where muscles and ligaments attach, allowing us to move around. The substance inside our bones is called marrow. Bone marrow is the living tissue that makes up the soft, spongy center of bones. Bone marrow is where red blood cells, white blood cells, and platelets are produced. These blood cells help keep us healthy. Red blood cells carry oxygen from the lungs to the body's tissues. White blood cells help us fight infection and disease. Platelets help control bleeding by forming blood clots.

When cancer spreads to your bones, it becomes harder for your body to stay healthy.

Commonly used drugs for breast cancer bone metastasis

Herceptin: It is a recombinant DNA-derived humanized monoclonal antibody. Its single-drug efficacy is similar to that of chemotherapy drugs, but it does not cause the adverse reactions of chemotherapy drugs such as hair loss, mucositis, and hematological toxicity, and patients have good tolerance.

Xeloda (capecitabine tablets): It is a new generation of oral fluoropyrimidine drugs, which can be quickly absorbed in the gastrointestinal tract in the form of original drugs and metabolized into anti-tumor active substances in the liver and tumor tissue. It has been approved in many countries for patients with advanced breast cancer who have failed taxane and anthracycline treatment.

Furui: It is a new generation aromatase inhibitor. Aromatase inhibitors are generally well tolerated. However, adverse reactions such as gastrointestinal disturbances, weakness, headache, hot flashes and musculoskeletal pain are common.

Sulai: The growth of breast cancer cells depends on the presence of estrogen. Estrogen in the circulation of postmenopausal women is mainly converted from androgens in the adrenal glands, liver, muscles and fat by aromatase in peripheral tissues. Therefore, inhibiting aromatase to prevent estrogen production is an effective selective treatment for postmenopausal hormone-dependent breast cancer. The drug can significantly reduce the level of estrogen in the blood circulation of menopausal women, but has no significant effect on the biosynthesis of corticosteroids in the adrenal glands.

Paclitaxel injection: Paclitaxel has been approved by the FDA for adjuvant treatment of advanced breast cancer. It can also be used to treat patients who have failed combined chemotherapy or relapsed within 6 months of adjuvant treatment. Common adverse reactions of paclitaxel are bone marrow suppression, myalgia, arthralgia, mucositis, nausea and vomiting, as well as hair loss and peripheral nerve damage.

What are the commonly used drugs after breast cancer bone metastasis? The above introduces the drugs after bone metastasis. The occurrence of bone metastasis indicates the severity of the disease, so effective measures should be taken for treatment, so that the disease can recover as soon as possible and reduce the patient's pain.