What are the causes of fibroids

Fibromas are currently capsule lesions located in the surface layer of the dermis. The boundaries are unclear and there are many differences from the surrounding normal tissues. The lower boundary is unclear, and the upper boundary and the surface layer of the dermis are often sandwiched between a variety of collagen soft fibers to gradually form a boundary zone. So, what are the causes of fibromas introduced below?

There are many causes of fibroids, but the surface of the tumor tissue sometimes adheres to each other. The cut surface is yellow-brown or other colors. Under the light microscope, soft fibroblasts and mature or collagen soft fibrous tissues formed by tissue hyperplasia may appear; there may be some indefinite expansion in the tumor tissue, and the cells on the surface of the dermis are more complex and changeable; some tumor cells have lightly stained plasma and larger lesions, and hemosiderin is deposited in the deep and external layers of the tumor cells. There is no obvious hyperplasia on the surface of the dermis above the lesion, and the skin protrusions are extended. Occasionally, nuclear mitotic damage is seen, but it is not uncommon.

It is also related to viral infection. In fibroids, there are a large number of immature mast cells in close contact with fibroblasts. In fibroblasts, developed and expanded rough endoplasmic reticulum can be seen, indicating active function. It is believed that the increase in mast cells may be the cause of fibrosis.

The nodules are located in the dermis without capsule, with unclear boundaries and obvious interlacing with the surrounding normal tissues; the lower boundary is clear. There is often a "boundary zone" composed of immature collagen fibers between the upper boundary and the epidermis, but the tumor tissue can sometimes be tightly connected to the epidermis. The cut surface is grayish white, yellowish brown or dark brown. Under the light microscope, fibroblasts, histiocytes, endothelial cells and mature or immature collagen fiber tissues in the proliferating lesion tissue can be seen; in the tumor tissue, there are more or less dilated capillaries, and the endothelial cells are obvious; some tumor cells have lightly stained cytoplasm with vacuoles, becoming typical foam cells (fat deposition); there are hemosiderin deposits inside and outside the tumor cells. The epidermis above the center of the lesion often has obvious hyperplasia, thickened spinous layer, and elongated skin processes. Occasionally, nuclear mitosis is seen, but it is atypical.