What causes fibroids

Fibromas originate from fibrous tissues, and are generally nodular in shape, bean-shaped in size, and hard in texture. The nature of fibroma lesions is simple and benign. From the pathological section, fibromas are mainly composed of fibroblasts and immature and mature collagen fibers, which are mostly arranged in a whorl pattern, with tissue cells and a small amount of capillaries in between. So, what causes fibromas?

1. Causes of disease:

1. The cause is unknown. Some cases may be related to minor local injuries, such as insect bites or blunt injuries. Some people also believe that it is related to viral infection. Ackerman believes that the occurrence of this disease is reactive rather than tumorous. Through electron microscopy, a large number of immature mast cells in the fibroid are in close contact with fibroblasts. Developed and expanded cystic rough endoplasmic reticulum can be seen in the fibroblasts, indicating active function. It is believed that the increase in mast cells may be the cause of fibrosis.

2. Pathogenesis

The nodules are located in the dermis, without capsule, with unclear boundaries, and are clearly intertwined with the surrounding normal tissues; the lower boundary is clear. There is often a boundary zone composed of immature collagen fibers between the upper boundary and the epidermis, but the tumor tissue can sometimes be tightly connected to the epidermis. The cut surface is grayish white, yellowish brown or dark brown.

Under the light microscope, fibroblasts, histiocytes, endothelial cells and mature or immature collagen fiber tissues can be seen in the lesion tissue; there are more or less dilated capillaries in the tumor tissue, and the endothelial cells are obvious; some tumor cells have light cytoplasm and vacuoles, becoming typical foam cells (fat deposition); there are hemosiderin deposits inside and outside the tumor cells. The epidermis above the center of the lesion often has obvious hyperplasia, thickened spinous layer, and elongated skin processes. Occasionally, nuclear mitosis is seen, but it is atypical.